Smith W C, Crombie I K, Tavendale R T, Gulland S K, Tunstall-Pedoe H D
Cardiovascular Epidemiology Unit, Ninewells Hospital and Medical School, Dundee.
BMJ. 1988 Jul 30;297(6644):329-30. doi: 10.1136/bmj.297.6644.329.
As part of a study of risk factors for coronary heart disease 24 hour urine collections were obtained from 7354 men and women aged 40-59 selected at random from 22 districts throughout Scotland (Scottish heart health study). The mean of two standardised measurements of blood pressure was related to the reported consumption of alcohol and measurements of height, weight, pulse rate, and electrolyte excretion. Several significant correlations were found with both systolic and diastolic pressure, but only the coefficients for age, body mass index, and pulse rate were greater than 0.1. Alcohol consumption showed a weak positive correlation with blood pressure in men. Sodium excretion showed a weak positive correlation with blood pressure in both sexes, and potassium excretion showed weak negative correlations. In multiple regression analysis age, pulse rate, body mass index, alcohol consumption, and potassium excretion had significant independent effects but sodium excretion did not. Although measuring blood pressure twice on one occasion and 24 hour urinary sodium excretion only once may have weakened any potential correlation, the most likely explantation of these results is that the relation between sodium and blood pressure in the population is weak and that potassium and alcohol are of greater importance.
作为一项冠心病风险因素研究的一部分，从苏格兰22个地区随机选取了7354名年龄在40至59岁之间的男性和女性，收集他们24小时的尿液（苏格兰心脏健康研究）。两次标准化血压测量的平均值与报告的酒精摄入量以及身高、体重、脉搏率和电解质排泄量相关。在收缩压和舒张压方面均发现了若干显著相关性，但只有年龄、体重指数和脉搏率的系数大于0.1。男性的酒精摄入量与血压呈弱正相关。钠排泄量在两性中均与血压呈弱正相关，而钾排泄量呈弱负相关。在多元回归分析中，年龄、脉搏率、体重指数、酒精摄入量和钾排泄量具有显著的独立影响，而钠排泄量则没有。尽管在同一时间测量两次血压且仅测量一次24小时尿钠排泄量可能削弱了任何潜在的相关性，但这些结果最可能的解释是，人群中钠与血压之间的关系较弱，而钾和酒精更为重要。
