Department of Microbiology and Infectious Diseases, Veterinary Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Institute for Biomedical Diagnostics and Research "GENOM," Travnik, Bosnia and Herzegovina.
Microb Drug Resist. 2020 Oct;26(10):1271-1274. doi: 10.1089/mdr.2019.0465. Epub 2020 May 15.
The objective of this study was to determine the minimum inhibitory concentrations (MICs) of nine antimicrobials (enrofloxacin, ciprofloxacin, norfloxacin, gentamicin, spectinomycin, oxytetracycline, tylosin, florfenicol, and tiamulin) against 24 isolates obtained from sheep and goats and to compare the resulting antimicrobial profiles. Enrofloxacin and ciprofloxacin had the lowest MIC values (<0.03 μg/mL) and MIC values (0.25 μg/mL) for all tested isolates. The highest MIC value (2 μg/mL) was obtained for florfenicol, while oxytetracycline and tylosin exhibited the highest MIC values (16 μg/mL). The MIC values for all fluoroquinolones and oxytetracycline were significantly lower for sheep isolates. Sheep isolates were considerably more susceptible to norfloxacin and tylosin than were goat isolates. This study demonstrated differences in antimicrobial susceptibilities between sheep and goat isolates, revealing in goat isolates to be less susceptible. The results suggest a possible link between antimicrobial profiles of isolates and their host ruminant species.
本研究旨在确定从绵羊和山羊中分离得到的 24 株分离株对 9 种抗菌药物（恩诺沙星、环丙沙星、诺氟沙星、庆大霉素、大观霉素、土霉素、泰乐菌素、氟苯尼考和替米考星）的最小抑菌浓度（MIC），并比较其抗菌谱。所有测试分离株的恩诺沙星和环丙沙星的 MIC 值最低（<0.03μg/mL）和 MIC 值（0.25μg/mL）。氟苯尼考的 MIC 值最高（2μg/mL），而土霉素和泰乐菌素的 MIC 值最高（16μg/mL）。所有氟喹诺酮类药物和土霉素对绵羊分离株的 MIC 值明显较低。绵羊分离株对诺氟沙星和泰乐菌素的敏感性明显高于山羊分离株。本研究表明绵羊和山羊分离株的抗菌药物敏感性存在差异，揭示山羊分离株的敏感性较低。研究结果表明，分离株的抗菌谱与其宿主反刍动物种类之间可能存在关联。
