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性别和年龄差异揭示了新冠疫情中的风险模式。

Gender and Age Differences Reveal Risk Patterns in COVID-19 Outbreak.

作者信息

Singh Yogendra, Gupta Gaurav, Mishra Anurag, Chellappan Dinesh Kumar, Dua Kamal

出版信息

Altern Ther Health Med. 2020 Aug;26(S2):54-55.

PMID:32412919
Abstract

By April 28th 2020, the global number of people that were viciously infected with the newfound novel corona virus (COVID-19) stood at a staggering 3 077 133 cases, as per the confirmed data released by the WHO. It has been reported that women from the Chinese Han population are associated with essential hypertension due to their relation with the 5 SNPs, namely, rs1514283, rs4646155, rs4646176, rs2285666, and rs879922, which belong to the ACE2 gene. The level of ACE2 activity was very low in normal healthy younger persons, and was reported to be increased in patients with cardiovascular diseases. Thus, there might be severe myocarditis, that may result in acute heart failure and cardiac complexities in the elderly subjects.

摘要

根据世界卫生组织发布的确诊数据,截至2020年4月28日,全球感染新型冠状病毒(COVID-19)的人数达到惊人的3077133例。据报道,中国汉族女性与原发性高血压有关,因为她们与属于ACE2基因的5个单核苷酸多态性(SNP),即rs1514283、rs4646155、rs4646176、rs2285666和rs879922有关。在正常健康的年轻人中,ACE2活性水平非常低,据报道在心血管疾病患者中会升高。因此,老年受试者可能会出现严重的心肌炎,这可能导致急性心力衰竭和心脏并发症。

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