Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
Vet Ophthalmol. 2020 Jul;23(4):682-689. doi: 10.1111/vop.12776. Epub 2020 May 15.
To provide an updated overview of feline orbital neoplasia, to compare diagnostic utility of cytology and histopathology, and to evaluate minimally invasive sampling modalities.
A medical records search was performed to identify cats with orbital neoplasia. Data were collected regarding signalment, diagnosis, vision status, imaging modalities, and sample collection methods. A reference population with orbital neoplasia was also identified via literature search for comparison with regard to final diagnosis.
Eighty-one cats met selection criteria and 140 cases were identified in the literature. In the study and reference populations, respectively, diagnoses were grouped as follows: round cell tumors 47% and 24%, epithelial tumors 38% and 40%, mesenchymal tumors 14% and 34%, and neurologic origin tumors 1% and 2%. The most common diagnoses in both groups were lymphoma and squamous cell carcinoma (SCC). Feline restrictive orbital myofibroblastic sarcoma (FROMS) was common in the reference population but not diagnosed in the study population. Cytology results were available for 41 cats; histopathology results were available for 65 cats. Both cytology and histopathology results were available for 25 cats, in 44% of which cytologic results were overturned. No significant complications were associated with any sampling method. Lack of cats with multiple samples available for histopathology limited comparison between tissue sampling methods.
Orbital neoplasia is common in cats, with round cell and epithelial tumors diagnosed most commonly in the study population. Histopathology is superior to cytology in providing a definitive diagnosis. Minimally invasive tissue biopsy techniques appear to be safe and effective.
提供猫眼眶肿瘤的最新概述，比较细胞学和组织病理学的诊断效用，并评估微创取样方式。
通过病历检索确定患有眼眶肿瘤的猫。收集了有关品种、诊断、视力状况、影像学方式和样本采集方法的数据。还通过文献检索确定了眼眶肿瘤的参考人群，以便就最终诊断进行比较。
81 只猫符合选择标准，文献中确定了 140 例。在研究和参考人群中，诊断分别分为以下几类：圆形细胞肿瘤 47%和 24%、上皮肿瘤 38%和 40%、间叶肿瘤 14%和 34%以及神经起源肿瘤 1%和 2%。两个群体中最常见的诊断均为淋巴瘤和鳞状细胞癌（SCC）。猫限制性眶肌纤维肉瘤（FROMS）在参考人群中常见，但在研究人群中未诊断。41 只猫的细胞学结果可用；65 只猫的组织病理学结果可用。25 只猫的细胞学和组织病理学结果均可用，其中 44%的细胞学结果被推翻。任何采样方法均未发生显著并发症。由于缺乏可用于组织病理学的多个样本，限制了组织采样方法之间的比较。
眼眶肿瘤在猫中很常见，研究人群中最常见的是圆形细胞和上皮肿瘤。组织病理学在提供明确诊断方面优于细胞学。微创组织活检技术似乎安全有效。
