Indiana University, Bloomington, IN, USA.
Cell. 2020 May 14;181(4):749-753. doi: 10.1016/j.cell.2020.04.040.
In 1991, Buck and Axel published a landmark study in Cell for work that was awarded the 2004 Nobel Prize. The identification of the olfactory receptors as the largest family of GPCRs catapulted olfaction into mainstream neurobiology. This BenchMark revisits Buck's experimental innovation and its surprising success at the time.
1991 年，巴克和阿克塞尔在《细胞》杂志上发表了一项具有里程碑意义的研究成果，该成果获得了 2004 年诺贝尔生理学或医学奖。嗅觉受体作为最大的 G 蛋白偶联受体家族被鉴定出来，这使得嗅觉研究成为神经生物学的主流。本研究亮点回顾了巴克的实验创新及其当时出人意料的成功。
