Antunes Gabriela, Simoes de Souza Fabio Marques
Laboratory of Neural Systems (SisNE), Department of Physics, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil.
Methods Cell Biol. 2016;132:127-45. doi: 10.1016/bs.mcb.2015.11.003. Epub 2015 Dec 24.
The guanine nucleotide protein (G protein)-coupled receptors (GPCRs) superfamily represents the largest class of membrane protein in the human genome. More than a half of all GPCRs are dedicated to interact with odorants and are termed odorant-receptors (ORs). Linda Buck and Richard Axel, the Nobel Prize laureates in physiology or medicine in 2004, first cloned and characterized the gene family that encode ORs, establishing the foundations to the understanding of the molecular basis for odor recognition. In the last decades, a lot of progress has been done to unravel the functioning of the sense of smell. This chapter gives a general overview of the topic of olfactory receptor signaling and reviews recent advances in this field.
鸟嘌呤核苷酸蛋白（G蛋白）偶联受体（GPCRs）超家族是人类基因组中最大的一类膜蛋白。所有GPCRs中超过一半专门用于与气味剂相互作用，被称为气味受体（ORs）。2004年诺贝尔生理学或医学奖获得者琳达·巴克和理查德·阿克塞尔首次克隆并鉴定了编码ORs的基因家族，为理解气味识别的分子基础奠定了基础。在过去几十年里，在揭示嗅觉功能方面取得了很大进展。本章对嗅觉受体信号传导这一主题进行了概述，并综述了该领域的最新进展。
