Zhang Chuanhai, He Xiaoyun, Sheng Yao, Xu Jia, Yang Cui, Zheng Shujuan, Liu Junyu, Li Haoyu, Ge Jianbing, Yang Minglan, Zhai Baiqiang, Xu Wentao, Luo Yunbo, Huang Kunlun
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), Ministry of Agriculture, Beijing 100083, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), Ministry of Agriculture, Beijing 100083, China.
iScience. 2020 May 22;23(5):101113. doi: 10.1016/j.isci.2020.101113. Epub 2020 Apr 28.
Brown adipose tissue (BAT) is a promising potential therapeutic target for the treatment of obesity and related metabolic diseases. Allicin, a natural product in garlic, has multiple biological and pharmacological functions. However, the role of allicin in the regulation of metabolic organs, particularly BAT activation, has not been well studied. Here, we show that allicin imparts a significant effect by inhibiting body weight gain, decreasing adiposity, maintaining glucose homeostasis, improving insulin resistance, and ameliorating hepatic steatosis in obese mice. These observations strongly correlate with the activation of BAT. Notably, allicin plays a role in BAT activation, which may partly contribute to the Sirt1-PGC1α-Tfam pathway. In addition, allicin can significantly increase the succinylation levels of UCP1 in BAT by inhibiting sirt5, whereas excess allicin induces autophagy/mitophagy and mitochondrial dysfunction. Thus, our findings point to allicin as a promising therapeutic approach for the treatment of obesity and metabolic disorders.
棕色脂肪组织（BAT）是治疗肥胖症及相关代谢性疾病的一个有前景的潜在治疗靶点。大蒜中的天然产物蒜素具有多种生物学和药理学功能。然而，蒜素在调节代谢器官，特别是BAT激活方面的作用尚未得到充分研究。在此，我们表明蒜素通过抑制肥胖小鼠体重增加、降低肥胖程度、维持血糖稳态、改善胰岛素抵抗和减轻肝脂肪变性发挥显著作用。这些观察结果与BAT的激活密切相关。值得注意的是，蒜素在BAT激活中起作用，这可能部分归因于Sirt1-PGC1α-Tfam途径。此外，蒜素可通过抑制sirt5显著增加BAT中UCP1的琥珀酰化水平，而过量蒜素会诱导自噬/线粒体自噬和线粒体功能障碍。因此，我们的研究结果表明蒜素是治疗肥胖症和代谢紊乱的一种有前景的治疗方法。
