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天然产物与癌症代谢异常：治疗靶点与作用机制。

Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of Action.

机构信息

Faculty of Allied Medical Sciences, Applied Science Private University, Amman 11931, Jordan.

Faculty of Health and Life Sciences, Inti International University, Nilai 71800, Negeri Sembilan, Malaysia.

出版信息

Int J Mol Sci. 2024 Sep 4;25(17):9593. doi: 10.3390/ijms25179593.

DOI:10.3390/ijms25179593
PMID:39273552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11394730/
Abstract

Cancer is characterized by uncontrolled cell proliferation and the dysregulation of numerous biological functions, including metabolism. Because of the potential implications of targeted therapies, the metabolic alterations seen in cancer cells, such as the Warburg effect and disruptions in lipid and amino acid metabolism, have gained attention in cancer research. In this review, we delve into recent research examining the influence of natural products on altered cancer metabolism. Natural products were selected based on their ability to target cancer's altered metabolism. We identified the targets and explored the mechanisms of action of these natural products in influencing cellular energetics. Studies discussed in this review provide a solid ground for researchers to consider natural products in cancer treatment alone and in combination with conventional anticancer therapies.

摘要

癌症的特征是细胞不受控制地增殖和许多生物功能失调，包括代谢。由于靶向治疗的潜在意义，癌症细胞中出现的代谢改变，如瓦博格效应和脂质及氨基酸代谢的紊乱，在癌症研究中受到关注。在这篇综述中，我们深入探讨了最近研究中天然产物对改变的癌症代谢的影响。天然产物是根据它们靶向癌症改变的代谢的能力选择的。我们确定了这些天然产物影响细胞能量学的靶点，并探讨了它们的作用机制。本综述中讨论的研究为研究人员提供了坚实的基础，使他们可以考虑将天然产物单独用于癌症治疗，以及与传统抗癌疗法联合使用。

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