Maki Shintaro, Kato Ineko, Enomoto Naosuke, Takakura Sho, Nii Masafumi, Tanaka Kayo, Tanaka Hiroaki, Hori Shinsuke, Matsuda Kana, Ueda Yukito, Sawada Hirofumi, Hirayama Masahiro, Sudo Akihiro, Ikeda Tomoaki
Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 5148507, Japan.
Department of Rehabilitation, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 5148507, Japan.
J Clin Med. 2020 May 13;9(5):1448. doi: 10.3390/jcm9051448.
To assess the long-term effects of tadalafil, a therapeutic agent for fetal growth restriction (FGR), we evaluated the developmental progress of 1.5-year-old infants whose mothers had taken tadalafil during pregnancy. Twenty-four infants were assessed. We evaluated infant body weight, height, and head circumference, and performed the Kyoto Scale of Psychological Development (KSPD) test, a standardized developmental assessment covering Postural-Motor (P-M), Cognitive-Adaptive (C-A), and Language-Social (L-S) functions. The sum score was converted to a developmental quotient (DQ). The mean gestational week of the included cases was 36.1 (29-39) weeks, and the mean birth weight was 1841 (874-2646) g. Twenty-one and 20 out of the 24 cases, respectively, attained body weight and height similar to those of age-matched normal infants (within the 3rd percentile); all cases caught up in head circumference. KSPD was performed for 18 cases at 1.5 years of corrected age. The mean DQ scores were 87 (in total): 82 in P-M, 90 in C-A, and 88 in L-S. The total DQ score in one case (5.6%) was less than 70, and ranged from 70 to 85 in five cases (27.7%), and was more than 85 in 11 cases (61.1%). The growth and development of infants born of tadalafil-treated mothers seem to show good progress at a corrected age of 1.5 years.
为评估胎儿生长受限（FGR）治疗药物他达拉非的长期影响，我们对母亲在孕期服用他达拉非的1.5岁婴儿的发育进展进行了评估。共评估了24名婴儿。我们评估了婴儿的体重、身高和头围，并进行了京都心理发育量表（KSPD）测试，这是一项涵盖姿势运动（P-M）、认知适应（C-A）和语言社交（L-S）功能的标准化发育评估。总分转换为发育商（DQ）。纳入病例的平均孕周为36.1（29 - 39）周，平均出生体重为1841（874 - 2646）g。24例病例中分别有21例和20例的体重和身高与年龄匹配的正常婴儿相似（在第3百分位数以内）；所有病例的头围均已追赶上。在矫正年龄1.5岁时对18例病例进行了KSPD测试。平均DQ分数总计为87分：P-M为82分，C-A为90分，L-S为88分。1例病例（5.6%）的总DQ分数低于70分，5例病例（27.7%）的分数在70至85分之间，11例病例（61.1%）的分数高于85分。母亲接受他达拉非治疗的婴儿在矫正年龄1.5岁时的生长和发育似乎进展良好。
