从 中分离得到的 clerodane 二萜类化合物及其抗炎活性。
Clerodane Diterpenoids from and Their Anti-Inflammatory Activity.
机构信息
Graduate Institute of Natural Products, Center for Natural Product Research and Development, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Graduate Institute of Natural Products, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
出版信息
Molecules. 2020 May 13;25(10):2288. doi: 10.3390/molecules25102288.
Plants of the genus are known to possess several medicinal effects. The constituents of the Taiwan endemic plant have never been studied. Therefore, was selected for our phytochemical investigation. Two new clerodane-type diterpenoids, named callihypolins A () and B (), along with seven known compounds were isolated from the leaves and twigs of the Lamiaceae plant and then characterized. The structures of compounds and were elucidated by spectroscopic data analysis, specifically, two-dimension nuclear magnetic resonance (NMR). The anti-inflammatory activity of compounds - based on the suppression of superoxide anion generation and elastase release was evaluated. Among the isolates, compounds - showed anti-inflammatory activity (9.52-32.48% inhibition at the concentration 10 μm) by suppressing superoxide anion generation and elastase release. Our findings not only expand the description of the structural diversity of the compounds present in plants of the genus but also highlight the possibility of developing anti-inflammatory agents from endemic species.
属于的植物被认为具有多种药用功效。台湾特有植物的成分从未被研究过。因此，选择用于我们的植物化学研究。从唇形科植物的叶子和小枝中分离出两种新的 clerodane 型二萜类化合物，命名为 callihypolins A () 和 B ()，并与 7 种已知化合物一起进行了鉴定。化合物和的结构通过光谱数据分析，特别是二维核磁共振 (NMR) 来阐明。基于对超氧阴离子生成和弹性蛋白酶释放的抑制作用，评估了化合物的抗炎活性。在分离出的化合物中，化合物 - 通过抑制超氧阴离子生成和弹性蛋白酶释放，显示出抗炎活性（在浓度 10 μm 时抑制率为 9.52-32.48%）。我们的研究结果不仅扩展了属植物中存在的化合物结构多样性的描述，还强调了从台湾特有物种中开发抗炎剂的可能性。
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