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HOXD9 通过转录激活 HMCN1 加剧宫颈癌的发展。

HOXD9 aggravates the development of cervical cancer by transcriptionally activating HMCN1.

机构信息

Department of Gynecology and Obstetrics, Affiliated Nanhua Hospital, University of South China, Hengyang, China -

Department of Gynecology and Obstetrics, Tongren Municipal People's Hospital, Tongren, China.

出版信息

Panminerva Med. 2022 Dec;64(4):532-536. doi: 10.23736/S0031-0808.20.03911-7. Epub 2020 May 14.

DOI:10.23736/S0031-0808.20.03911-7
PMID:32414224
Abstract

BACKGROUND

To detect HOXD9 levels in cervical cancer species and to explore the relationship between HOXD9 level and prognosis in cervical cancer patients. We also verify the influence of HOXD9 on metastatic abilities in cervical cancer.

METHODS

HOXD9 levels in cervical cancer species were detected. Its influence on clinical features and prognosis in cervical cancer patients was analyzed. Regulatory effects of HOXD9 on migratory and invasive capacities in C33-A and HeLa cells were evaluated by Transwell assay. Subsequently, the downstream gene of HOXD9 was predicted by bioinformatics analysis and confirmed by luciferase assay. The involvement of HMCN1 in regulating metastatic ability in cervical cancer cells was finally explored by rescue experiments.

RESULTS

HOXD9 was upregulated in cervical cancer species and its level was positively correlated to rates of lymphatic metastasis and distant metastasis. High level of HOXD9 in cervical cancer patients predicted a poor prognosis. Overexpression of HOXD9 promoted migratory and invasive capacities in cervical cancer cells. HMCN1 was identified to be the downstream gene binding HOXD9. It was responsible for HOXD9-regulated metastasis in cervical cancer.

CONCLUSIONS

HOXD9 is upregulated in cervical cancer species. Its level is closely linked to metastasis rate and poor prognosis in cervical cancer patients. Through positively regulating HMCN1 level, HOXD9 stimulates migratory and invasive capacities in cervical cancer cells.

摘要

背景

检测宫颈癌组织中 HOXD9 的水平，探讨 HOXD9 水平与宫颈癌患者预后的关系。我们还验证了 HOXD9 对宫颈癌转移能力的影响。

方法

检测宫颈癌组织中 HOXD9 的水平。分析 HOXD9 对宫颈癌患者临床特征和预后的影响。通过 Transwell 实验评估 HOXD9 对 C33-A 和 HeLa 细胞迁移和侵袭能力的调节作用。随后，通过生物信息学分析预测 HOXD9 的下游基因，并通过荧光素酶实验进行验证。最后通过挽救实验探讨 HMCN1 在调节宫颈癌细胞转移能力中的作用。

结果

HOXD9 在宫颈癌组织中上调，其水平与淋巴结转移和远处转移率呈正相关。宫颈癌患者中 HOXD9 水平高提示预后不良。过表达 HOXD9 促进宫颈癌细胞的迁移和侵袭能力。鉴定出 HMCN1 是结合 HOXD9 的下游基因。它负责 HOXD9 调节的宫颈癌转移。

结论

HOXD9 在宫颈癌组织中上调。其水平与宫颈癌患者的转移率和预后不良密切相关。通过正向调节 HMCN1 水平，HOXD9 刺激宫颈癌细胞的迁移和侵袭能力。

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