Department of Surgery, Minhang Hospital, Fudan University, Shanghai 201199, China; Department of Hepatobiliary-Pancreatic & Minimally Invasive Surgery, Affiliated Zhejiang Provincial People's Hospital, Hangzhou Medical School, Hangzhou 310014, China.
Department of Hepatobiliary-Pancreatic & Minimally Invasive Surgery, Affiliated Zhejiang Provincial People's Hospital, Hangzhou Medical School, Hangzhou 310014, China; Center for Clinical Medical Research, Affiliated Zhejiang Provincial People's Hospital, Hangzhou Medical School, Hangzhou 310014, China.
Hepatobiliary Pancreat Dis Int. 2020 Jun;19(3):218-228. doi: 10.1016/j.hbpd.2020.04.002. Epub 2020 May 3.
Hepatectomy and liver transplantation (LT) are the two most commonly performed surgical procedures for various hepatic lesions. microRNA (miRNA) and long non-coding RNA (lncRNA) have been gradually unveiled their roles as either biomarkers for early diagnosis or potentially therapeutic tools to manipulate gene expression in many disease entities. This review aimed to discuss the effects of miRNA or lncRNA in the hepatectomy and LT fields.
We did a literature search from 1990 through January 2018 to summarize the currently available evidence with respect to the effects of miRNA and lncRNA in liver regeneration after partial hepatectomy, as well as their involvement in several key issues related to LT, including ischemia-reperfusion injury, allograft rejection, tolerance, recurrence of original hepatic malignancies, etc. RESULTS: Certain miRNAs and lncRNAs are actively involved in the regulation of various aspects of liver resection and transplantation. During the process of liver regeneration after hepatectomy, the expression of miRNAs and lncRNAs shows dynamic changes.
It is now clear that miRNAs and lncRNAs orchestrate in various aspects of the pathophysiological process of LT and hepatectomy. Better understanding of the underlying mechanism and future clinical trials may strengthen their positions as either biomarkers or potential therapeutic targets in the management of complications after liver surgery.
肝切除术和肝移植（LT）是治疗各种肝脏病变最常用的两种手术方法。microRNA（miRNA）和长链非编码 RNA（lncRNA）已逐渐揭示其作为早期诊断的生物标志物或潜在的治疗工具的作用，以调控许多疾病实体中的基因表达。本综述旨在讨论 miRNA 或 lncRNA 在肝切除术和 LT 领域中的作用。
我们从 1990 年到 2018 年 1 月进行了文献检索，以总结目前关于 miRNA 和 lncRNA 在部分肝切除术后肝再生中的作用的现有证据，以及它们在与 LT 相关的几个关键问题中的作用，包括缺血再灌注损伤、同种异体移植排斥反应、耐受、原发性肝恶性肿瘤的复发等。
某些 miRNA 和 lncRNA 积极参与调节肝切除术和移植的各个方面。在肝切除术后肝再生过程中，miRNA 和 lncRNA 的表达呈现动态变化。
现在很明显，miRNA 和 lncRNA 在 LT 和肝切除术的病理生理过程的各个方面进行协调。对潜在机制的更好理解和未来的临床试验可能会加强它们作为肝手术后并发症的生物标志物或潜在治疗靶点的地位。
