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活体供肾移植:让我们来探讨一下。

Living donor kidney transplantation: Let's talk about it.

作者信息

Sharma Videha, Roy Reuben, Piscoran Oana, Summers Angela, van Dellen David, Augustine Titus

机构信息

Manchester University Hospitals NHS Foundation Trust, Manchester, UK and University of Manchester, Manchester, UK

Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

出版信息

Clin Med (Lond). 2020 May;20(3):346-348. doi: 10.7861/clinmed.2020-0047.

DOI:10.7861/clinmed.2020-0047
PMID:32414729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7354017/
Abstract

Transplantation is the preferred treatment option for end-stage renal disease as it offers superior results and patient reported outcomes in comparison to dialysis. Patients treated with a transplant live longer, healthier and more independent lives. Transplantation is also more cost-effective, reducing the overall burden of renal disease. Despite the rising incidence of renal failure, the uptake of living donor kidney transplantation has been static across the UK for several years. Among transplantation, living donation offers a number of advantages compared with deceased donor transplantation. The procedure is more likely to be performed pre-dialysis and the elective nature allows for better perioperative planning. Awareness for living donation processes among healthcare professionals, patients and the public appears to be poor. Sharing information regarding the process will help educate colleagues, dispel myths and, crucially, allow patients the opportunity to talk about this treatment option with their hospital doctor.

摘要

移植是终末期肾病的首选治疗方案,因为与透析相比,它能带来更好的治疗效果和患者报告结局。接受移植治疗的患者寿命更长、生活更健康、更独立。移植也更具成本效益,减轻了肾病的总体负担。尽管肾衰竭发病率不断上升,但活体供肾移植在英国的接受率多年来一直停滞不前。在移植中,与 deceased donor transplantation(此处原文有误,可能是“deceased donor transplantation”,意为“尸体供肾移植”)相比,活体捐赠具有许多优势。该手术更有可能在透析前进行,且其选择性性质允许进行更好的围手术期规划。医疗保健专业人员、患者和公众对活体捐赠过程的认知似乎较差。分享有关该过程的信息将有助于教育同事、消除误解,至关重要的是,让患者有机会与他们的医院医生谈论这种治疗选择。

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1
Living donor kidney transplantation: Let's talk about it.活体供肾移植:让我们来探讨一下。
Clin Med (Lond). 2020 May;20(3):346-348. doi: 10.7861/clinmed.2020-0047.
2
Live donor kidney transplantation. Situation analysis and roadmap.活体供肾移植。情况分析与路线图。
Nefrologia (Engl Ed). 2022 Jan-Feb;42(1):85-93. doi: 10.1016/j.nefroe.2022.02.002. Epub 2022 Apr 2.
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Patients' willingness to talk to others about living kidney donation.患者与他人谈论活体肾捐献的意愿。
Prog Transplant. 2008 Mar;18(1):25-31. doi: 10.1177/152692480801800107.
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The experiences of adults who are on dialysis and waiting for a renal transplant from a deceased donor: a systematic review.接受透析治疗并等待已故捐赠者肾脏移植的成年人的经历:一项系统综述。
JBI Database System Rev Implement Rep. 2015 Mar 12;13(2):169-211. doi: 10.11124/jbisrir-2015-1973.
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Increasing access to kidney transplantation in countries with limited resources: the Indian experience with kidney paired donation.在资源有限的国家增加肾移植的可及性:印度肾对肾捐赠的经验
Nephrology (Carlton). 2014 Oct;19(10):599-604. doi: 10.1111/nep.12307.
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An economic assessment of contemporary kidney transplant practice.当代肾移植实践的经济评估。
Am J Transplant. 2018 May;18(5):1168-1176. doi: 10.1111/ajt.14702. Epub 2018 Mar 31.
7
Variation in Dialysis Exposure Prior to Nonpreemptive Living Donor Kidney Transplantation in the United States and Its Association With Allograft Outcomes.美国非优先活体供肾移植前透析暴露的差异及其与移植物结局的关系。
Am J Kidney Dis. 2018 May;71(5):636-647. doi: 10.1053/j.ajkd.2017.11.012. Epub 2018 Feb 1.
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Is living kidney donation the answer to the economic problem of end-stage renal disease?活体肾捐赠是终末期肾病经济问题的答案吗?
Semin Nephrol. 2009 Sep;29(5):533-8. doi: 10.1016/j.semnephrol.2009.06.010.
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Living Kidney Donation: Strategies to Increase the Donor Pool.活体肾脏捐献:增加供体池的策略。
Surg Clin North Am. 2019 Feb;99(1):37-47. doi: 10.1016/j.suc.2018.09.003.
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Living or deceased donor kidney transplantation in children.儿童活体或尸肾移植。
Curr Opin Pediatr. 2019 Apr;31(2):232-236. doi: 10.1097/MOP.0000000000000740.

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Association of In Vivo Kidney Stiffness Measured by Multifrequency MR Elastography and Long-Term Renal Function in Transplant Recipients and Living Donors.多频磁共振弹性成像测量的体内肾硬度与移植受者和活体供者长期肾功能的相关性
J Magn Reson Imaging. 2025 Sep;62(3):792-799. doi: 10.1002/jmri.29799. Epub 2025 Apr 17.
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Performance of the New CKD-EPI Creatinine-and Cystatin C-based Glomerular Filtration Rate Estimation Equation in Living Kidney Donor Candidate.新型基于肌酐和胱抑素C的慢性肾脏病流行病学协作组肾小球滤过率估计方程在活体肾供体候选者中的性能
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Racialized and Immigrant Status and the Pursuit of Living Donor Kidney Transplant - a Canadian Cohort Study.种族化与移民身份以及活体肾移植的寻求——一项加拿大队列研究
Kidney Int Rep. 2024 Feb 1;9(4):960-972. doi: 10.1016/j.ekir.2024.01.044. eCollection 2024 Apr.
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A Conceptual Framework for Evaluating National Organ Donation and Transplantation Programs.评估国家器官捐赠和移植计划的概念框架。
Transpl Int. 2023 May 25;36:11006. doi: 10.3389/ti.2023.11006. eCollection 2023.

本文引用的文献

1
The 21st UK Renal Registry Annual Report: A Summary of Analyses of Adult Data in 2017.《英国肾脏注册机构第21次年度报告:2017年成人数据分析总结》
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7
Summary of the British Transplantation Society/Renal Association U.K. guidelines for living donor kidney transplantation.英国移植学会/英国肾脏协会活体供肾移植指南摘要。
Transplantation. 2012 Apr 15;93(7):666-73. doi: 10.1097/TP.0b013e318247a7b7.
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Living donor renal transplantation: recent developments and perspectives.活体供肾移植:最新进展与展望
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Impact of cadaveric renal transplantation on survival in patients listed for transplantation.尸体肾移植对列入移植名单患者生存率的影响。
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