Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, 300211, People's Republic of China.
Department of Clinical Research, Federal University of Uberlândia, Uberlândia, Brazil.
Curr Atheroscler Rep. 2020 May 7;22(3):14. doi: 10.1007/s11883-020-00842-y.
Coronavirus disease 2019 (COVID-19), a new infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has reached a pandemic status. Although SARSCoV-2 causes primarily respiratory problems, concurrent cardiac injury cannot be ignored since it may be an independent predictor for adverse outcomes. To resolve these issues, we aim to summarize the prevalence and its underlying mechanisms of acute cardiac injury in the setting of SARS-CoV-2 infection.
The main clinical manifestation of SARS-CoV-2 infection is pneumonia, cardiovascular complications have also been identified in the earliest reported cases from Wuhan, the epicenter of the outbreak. Given the SARS-CoV-2 likely uses the angiotensin-converting enzyme-2 (ACE2) receptors as its host receptor, ACE2-related signaling pathways may play a key role in mediating myocardial injury. SARS-CoV-2 infection related acute cardiac injury cannot be ignored, and its underlying mechanisms remain speculated. We would suggest that health professionals investigate cardiac function as part of the routine care.
由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的新型传染病 2019 年冠状病毒病（COVID-19）已达到大流行状态。虽然 SARS-CoV-2 主要引起呼吸道问题，但同时存在的心脏损伤也不容忽视，因为它可能是不良预后的独立预测因素。为了解决这些问题，我们旨在总结 SARS-CoV-2 感染时急性心脏损伤的流行情况及其潜在机制。
SARS-CoV-2 感染的主要临床表现为肺炎，在疫情中心武汉最早报告的病例中也发现了心血管并发症。鉴于 SARS-CoV-2 可能使用血管紧张素转换酶 2（ACE2）受体作为其宿主受体，ACE2 相关信号通路可能在介导心肌损伤中发挥关键作用。SARS-CoV-2 感染相关的急性心脏损伤不容忽视，其潜在机制仍在推测中。我们建议卫生专业人员将心脏功能检查作为常规护理的一部分。
