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ACE2 在胰腺中的表达可能导致 SARS-CoV-2 感染后的胰腺损伤。

ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection.

机构信息

Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Hubei Province for the Clinical Medicine Research Center of Hepatic Surgery, Wuhan, Hubei, China.

Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Hubei Province for the Clinical Medicine Research Center of Hepatic Surgery, Wuhan, Hubei, China.

出版信息

Clin Gastroenterol Hepatol. 2020 Aug;18(9):2128-2130.e2. doi: 10.1016/j.cgh.2020.04.040. Epub 2020 Apr 22.

DOI:10.1016/j.cgh.2020.04.040
PMID:32334082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7194639/
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus that causes coronavirus disease 2019 (COVID-19) in human beings, has caused a serious public health issue. Attention to pancreatic injury is lacking, which may impact patients' prognosis. In this study, we explored the expression and distribution of angiotensin-converting enzyme 2 (ACE2), the receptor of SARS-CoV-2, in the pancreas. Combined with clinical data, we showed that pancreatic injury can occur in some COVID-19 patients.

摘要

严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)是一种新型冠状病毒,可导致人类 2019 年冠状病毒病(COVID-19),已造成严重的公共卫生问题。目前对胰腺损伤的关注度不足,这可能影响患者的预后。本研究探讨了血管紧张素转换酶 2(ACE2),即 SARS-CoV-2 的受体,在胰腺中的表达和分布。结合临床资料,我们表明一些 COVID-19 患者可发生胰腺损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/7194639/4d22bf43aab1/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/7194639/4d22bf43aab1/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd39/7194639/4d22bf43aab1/gr1_lrg.jpg

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本文引用的文献

1
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2
Comprehensive Integration of Single-Cell Data.单细胞数据的综合整合。
Cell. 2019 Jun 13;177(7):1888-1902.e21. doi: 10.1016/j.cell.2019.05.031. Epub 2019 Jun 6.
3
CellMarker: a manually curated resource of cell markers in human and mouse.细胞标记物数据库:人类和小鼠细胞标记物的人工整理资源。
非胰腺性高胰脂肪酶血症(NPHL)中基于血液学参数的炎症评分——预后取决于血液。
Biomedicines. 2025 Jul 14;13(7):1719. doi: 10.3390/biomedicines13071719.
4
Causal relationship between COVID-19, vaccination, and 20 digestive diseases: a comprehensive two-sample Mendelian randomization study.2019冠状病毒病、疫苗接种与20种消化系统疾病之间的因果关系:一项全面的两样本孟德尔随机化研究
Virol J. 2025 Jun 30;22(1):213. doi: 10.1186/s12985-025-02847-y.
5
Post-COVID Metabolic Fallout: A Growing Threat of New-Onset and Exacerbated Diabetes.新冠后代谢后遗症:新发和加重型糖尿病的威胁日益增加。
Biomedicines. 2025 Jun 16;13(6):1482. doi: 10.3390/biomedicines13061482.
6
DiabetesOmic: A comprehensive multi-omics diabetes database.糖尿病组学:一个全面的多组学糖尿病数据库。
Comput Struct Biotechnol J. 2025 May 9;27:2147-2154. doi: 10.1016/j.csbj.2025.05.008. eCollection 2025.
7
COVID-19: Beyond Respiratory Tract.新冠病毒肺炎:超越呼吸道
J Dig Endosc. 2020 Mar;11(1):24-26. doi: 10.1055/s-0040-1712550. Epub 2020 May 16.
8
Pathophysiological Mechanisms Linking COVID-19 and Acute Surgical Abdomen: A Literature Review.连接新冠病毒疾病与急性外科急腹症的病理生理机制:文献综述
Life (Basel). 2025 Apr 27;15(5):707. doi: 10.3390/life15050707.
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4
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5
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6
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World J Gastroenterol. 2010 May 7;16(17):2094-9. doi: 10.3748/wjg.v16.i17.2094.
7
Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes.严重急性呼吸综合征冠状病毒与其受体结合会损伤胰岛细胞,导致急性糖尿病。
Acta Diabetol. 2010 Sep;47(3):193-9. doi: 10.1007/s00592-009-0109-4. Epub 2009 Mar 31.
8
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Clin Gastroenterol Hepatol. 2007 Jun;5(6):648-61; quiz 644. doi: 10.1016/j.cgh.2006.11.023. Epub 2007 Mar 28.
9
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Diabet Med. 2006 Jun;23(6):623-8. doi: 10.1111/j.1464-5491.2006.01861.x.