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3D生物打印在治疗新冠肺炎心肌损伤患者方面优于心脏细胞治疗和传统组织工程的前景。

Prospect of 3D bioprinting over cardiac cell therapy and conventional tissue engineering in the treatment of COVID-19 patients with myocardial injury.

作者信息

Akter Fariya, Araf Yusha, Naser Iftekhar Bin, Promon Salman Khan

机构信息

Biotechnology Program, Department of Mathematics and Natural Sciences, Brac University, Dhaka, Bangladesh.

Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh.

出版信息

Regen Ther. 2021 Dec;18:447-456. doi: 10.1016/j.reth.2021.09.007. Epub 2021 Sep 30.

Abstract

Due to multiple mutations of SARS-CoV-2, the mystery of defeating the virus is still unknown. Cardiovascular complications are one of the most concerning effects of COVID-19 recently, originating from direct and indirect mechanisms. These complications are associated with long-term Cardio-vascular diseases and can induce sudden cardiac death in both infected and recovered COVID-19 patients. The purpose of this research is to do a competitive analysis between conventional techniques with the upgraded alternative 3D bioprinting to replace the damaged portion of the myocardium. Additionally, this study focuses on the potential of 3D bioprinting to be a novel alternative. Finally, current challenges and future perspective of 3D bioprinting technique is briefly discussed.

摘要

由于新冠病毒的多种突变,战胜该病毒的奥秘仍不为人知。心血管并发症是近期新冠肺炎最令人担忧的影响之一,其源于直接和间接机制。这些并发症与长期心血管疾病相关,可导致新冠肺炎感染患者和康复患者的心源性猝死。本研究的目的是对传统技术与升级后的替代技术3D生物打印进行对比分析,以替代受损的心肌部分。此外,本研究聚焦于3D生物打印成为一种新型替代方案的潜力。最后,简要讨论了3D生物打印技术当前面临的挑战和未来前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da79/8551545/b98144823d00/gr1.jpg

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