Am J Epidemiol. 2020 Dec 1;189(12):1568-1570. doi: 10.1093/aje/kwaa081.
The development of tools for power and sample-size calculations for mediation analysis has lagged far behind the development of methods. The accompanying paper by Rudolph et al. (Am J Epidemiol. 2020;189(12):1559-1567) is a helpful contribution in using simulations as a tool for power calculations for more complex methods and settings. Much work remains to be done in the development of easy-to-use packages and simple online websites for carrying out power and sample-size calculations for mediation analysis. Much remains to be learned with respect to the relative power of different methods in different settings. There will likely be feedback between these 2 important frontiers of the tools we have available and of our understanding of power when conducting mediation analysis.
工具的开发用于调解分析的权力和样本大小的计算远远落后于方法的发展。鲁道夫等人的附带文件。 （美国流行病学杂志。 2020; 189（12）：1559-1567）作为一种工具，有助于使用模拟进行更复杂的方法和设置的功率计算。在开发用于调解分析的易于使用的软件包和简单的在线网站方面，还有很多工作要做。在不同的设置中，不同方法的相对功率还有很多需要了解。在进行调解分析时，我们可以使用的工具的这两个重要前沿领域以及我们对功率的理解之间可能会存在反馈。
