Alefishat Eman, S Jarab Anan, Abu Farha Rana
Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman, Jordan.
Department of Pharmacology, College of Medicine and Health Science, Khalifa University, Abu Dhabi, United Arab Emirates.
Int J Clin Pract. 2020 Sep;74(9):e13532. doi: 10.1111/ijcp.13532. Epub 2020 Jul 14.
Hypertension (HTN) is a major risk factor for cardiovascular disease, it is an epidemic health problem with 1 billion people affected worldwide. Limited studies have examined the impact of HTN on physical, psychological and social functioning of HTN patients. Furthermore, little is known about factors that impair these domains among these patients. Thus, the aim of the present study is to assess health-related quality of life (HRQoL) and to explore predictors of poor HRQoL in patients with HTN in Jordan.
Hypertensive patients visiting cardiology and internal medicine departments were recruited from three major hospitals in Jordan. Patients' Socio-demographics and medical data were collected via direct patient encounters and medical records. The validated Arabic version of EQ-5D tool was used to assess HRQoL. Simple linear regression was performed to explore the factors associated with poor HRQoL.
The mean score of the EQ-5D index of the 300 participants was 0.732 (SD = 0.29, range from -0.594 to 1.0). While extreme problems were only reported by 10% of the participants, most of them reported "some problems" through the five dimensions with the highest percentage (43.3%) for mobility dimension. Gender, monthly income, number of medical conditions, number of medications, number of HTN medications, duration of HTN and the presence of any atherosclerotic cardiovascular diseases were significantly associated with the EQ-5D index value (P-value <.05).
The current study highlights factors that negatively impact HRQoL in patients with HTN. Such findings should provide useful information for future pharmaceutical care intervention programmes aimed at improving HRQoL and other health outcomes in patients with HTN.
高血压是心血管疾病的主要危险因素,是一个全球性的流行健康问题,全球有10亿人受其影响。针对高血压对患者身体、心理和社会功能影响的研究有限。此外,对于损害这些患者上述方面的因素也知之甚少。因此,本研究的目的是评估约旦高血压患者的健康相关生活质量(HRQoL),并探索HRQoL较差的预测因素。
从约旦的三家主要医院招募心内科和内科门诊的高血压患者。通过直接接触患者和查阅病历收集患者的社会人口统计学和医疗数据。使用经过验证的阿拉伯语版EQ - 5D工具评估HRQoL。进行简单线性回归以探索与HRQoL较差相关的因素。
300名参与者的EQ - 5D指数平均得分为0.732(标准差=0.29,范围从 - 0.594至1.0)。虽然只有10%的参与者报告有极端问题,但大多数人在五个维度上报告了“一些问题”,其中活动能力维度的比例最高(43.3%)。性别、月收入、疾病数量、用药数量、高血压用药数量、高血压病程以及是否存在任何动脉粥样硬化性心血管疾病与EQ - 5D指数值显著相关(P值<.05)。
本研究强调了对高血压患者HRQoL产生负面影响的因素。这些发现应为未来旨在改善高血压患者HRQoL和其他健康结局的药学服务干预项目提供有用信息。