College of Pharmacy, Jinan University, Guangzhou, China.
Beijing Advanced Innovation Center for Food and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Qual Life Res. 2019 Aug;28(8):2069-2080. doi: 10.1007/s11136-019-02139-3. Epub 2019 Mar 4.
Hypertension is a major global public health problem, including rural China. However, studies examining health-related quality of life (HRQoL) for patients with hypertension have been mostly conducted in urban populations. This study aimed to use the EuroQol five-dimensional-five-level (EQ-5D-5L) and its recently developed Chinese value set to analyze HRQoL and its influencing factors among hypertensive population in rural China.
This is a cross-sectional population-based survey. Standard interview of participants was conducted from July to September 2016 in Donghai County's 334 villages of Jiangsu Province, China. Data collection included the EQ-5D-5L, along with sociodemographic characteristics and disease-related factors such as duration of hypertension, antihypertensive treatment and comorbid conditions. The Tobit regression model was employed to analyze potential influencing factors on HRQoL.
A total of 16,596 adults (18 years and older) with hypertension participated in this study. 62.4% were women. The mean utility score was 0.85 (standard deviation [SD] = 0.23). The proportion of participants reporting pain/discomfort problems was highest, while least patients reported problems in self-care dimension. Females, elderly, illiterate patients, ex-smokers and patients with longer duration of hypertension or comorbidities scored lower on HRQoL than others. Stroke, heart failure and coronary heart disease were associated with a larger negative impact on HRQoL among all comorbidities.
The HRQoL was lower in this rural hypertensive population than previously reported urban counterparts. To improve the HRQoL of hypertensive patients in rural areas, it is important to control hypertension and prevent its associated co-morbidities. More attention needs to be directed to elderly female patients with less education who scored much lower HRQoL than their male counterparts.
高血压是一个全球性的重大公共卫生问题，包括中国农村。然而，研究高血压患者的健康相关生活质量（HRQoL）的研究大多是在城市人群中进行的。本研究旨在使用欧洲五维健康量表（EQ-5D-5L）及其最近开发的中国价值集来分析中国农村高血压人群的 HRQoL 及其影响因素。
这是一项横断面的基于人群的调查。2016 年 7 月至 9 月，标准访谈在江苏省东海县的 334 个村庄进行。数据收集包括 EQ-5D-5L 以及社会人口统计学特征和疾病相关因素，如高血压持续时间、抗高血压治疗和合并症。采用 Tobit 回归模型分析 HRQoL 的潜在影响因素。
共有 16596 名成年高血压患者（18 岁及以上）参加了这项研究。62.4%是女性。平均效用评分是 0.85（标准差[SD] = 0.23）。报告疼痛/不适问题的患者比例最高，而自我护理维度的患者比例最低。女性、老年人、文盲患者、曾经吸烟者以及高血压持续时间较长或合并症较多的患者 HRQoL 评分较低。与所有合并症相比，中风、心力衰竭和冠心病对 HRQoL 的负面影响更大。
与先前报道的城市高血压患者相比，农村高血压患者的 HRQoL 较低。为了提高农村高血压患者的 HRQoL，控制高血压和预防其相关合并症非常重要。需要更多地关注那些 HRQoL 评分较低的农村老年女性患者，她们的 HRQoL 明显低于男性患者。
