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情绪情景式记忆成功编码和提取的神经关联:神经影像学研究的 SDM 元分析。

Neural correlates of successful emotional episodic encoding and retrieval: An SDM meta-analysis of neuroimaging studies.

机构信息

Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA, 30322, USA.

Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA, 30322, USA.

出版信息

Neuropsychologia. 2020 Jun;143:107495. doi: 10.1016/j.neuropsychologia.2020.107495. Epub 2020 May 13.

Abstract

Episodic memory for emotional events is typically enhanced and engages additional brain mechanisms relative to episodic memory for neutral events. Many functional magnetic resonance imaging (fMRI) studies have probed the neural basis of this emotional enhancement effect on encoding processes, while relatively fewer studies have examined retrieval. Neuroimaging meta-analysis methods can summarize the brain regions associated with emotional episodic memory that are consistently activated across multiple studies. A previous ALE (Activation Likelihood Estimation) meta-analysis identified consistent activations associated with successful encoding of episodic emotional memory in the amygdala, hippocampus, and in multiple neocortical regions (Murty et al., 2010). However, since that study, meta-analysis methods have improved, and many new relevant neuroimaging studies have been published. Moreover, although qualitative reviews have summarized brain activations related to the successful retrieval of emotional episodic memory, no corresponding quantitative meta-analyses have yet been reported. Here we conducted neuroimaging meta-analyses of successful emotional memory encoding and rretrieval using Seed-based d Mapping (SDM). Relevant neuroimaging studies reporting whole-brain fMRI correlates of successful encoding and retrieval of emotional episodic memory were selected for analysis. For successful emotional memory encoding, SDM activations were found bilaterally in the medial temporal lobe (amygdala, hippocampus, entorhinal cortex, perirhinal cortex, and parahippocampal cortex), bilaterally in visual processing regions (middle temporal, gyrus, fusiform gyrus and occipital cortex) and bilaterally in the temporal pole, orbitofrontal cortex, insula, putamen, and the inferior and middle temporal gyri. In contrast to the prior meta-analysis, SDM activations were not observed in the inferior frontal gyrus or in parietal regions. For successful emotional episodic memory retrieval, SDM activations were observed in the medial temporal lobe (bilateral amygdala, left hippocampus, and left entorhinal cortex and perirhinal cortex), visual processing regions (bilateral occipital cortex and right middle temporal gyrus), prefrontal cortex (bilateral orbitofrontal cortex, bilateral inferior frontal gyrus, bilateral precentral gyrus, left middle frontal gyrus, right frontal pole) and other regions in the left hemisphere including the temporal pole, insula, putamen, angular gyrus, and parietal opercular cortex. Considerable overlap was observed between the encoding and retrieval meta-analysis maps in the medial temporal lobe (bilateral amygdala, left hippocampus, entorhinal, and perirhinal cortex), visual processing regions (bilateral occipital cortex, right middle temporal gyrus), and other regions including the left orbitofrontal cortex, left insula, left putamen, left pallidum, and left temporal pole. The current findings add to current understanding of the role of the amygdala, hippocampus, and neocortical regions in the successful encoding and retrieval of emotional episodic memory, clarify and provide an important summary of the current literature in this area, and have implications for current theories of emotional episodic memory encoding and retrieval.

摘要

情景记忆对情绪事件的记忆通常会增强,并涉及到更多的大脑机制,而不是对中性事件的情景记忆。许多功能磁共振成像(fMRI)研究已经探讨了编码过程中这种情绪增强效应的神经基础,而相对较少的研究则探讨了检索。神经影像学荟萃分析方法可以总结与情绪情景记忆相关的大脑区域,这些区域在多个研究中始终得到激活。先前的 ALE(激活似然估计)荟萃分析确定了与情景情绪记忆成功编码相关的一致激活,这些激活位于杏仁核、海马体和多个新皮层区域(Murty 等人,2010 年)。然而,自该研究以来,荟萃分析方法已经得到了改进,并且已经发表了许多新的相关神经影像学研究。此外,尽管定性综述总结了与情绪情景记忆成功检索相关的大脑激活,但尚未报告相应的定量荟萃分析。在这里,我们使用基于种子的 d 映射(SDM)对成功的情绪记忆编码和检索进行神经影像学荟萃分析。选择了报告成功编码和检索情绪情景记忆的全脑 fMRI 相关性的相关神经影像学研究进行分析。对于成功的情绪记忆编码,SDM 激活双侧在颞叶内侧(杏仁核、海马体、内嗅皮层、旁海马回和海马旁回),双侧在视觉处理区域(中颞叶、梭状回和枕叶)和双侧在颞极、眶额皮层、岛叶、壳核和颞中回、颞下回。与先前的荟萃分析不同,SDM 激活未在额下回或顶叶区域观察到。对于成功的情绪情景记忆检索,SDM 激活在颞叶内侧(双侧杏仁核、左侧海马体和左侧内嗅皮层和旁海马回)、视觉处理区域(双侧枕叶和右侧中颞叶)、前额叶皮层(双侧眶额皮层、双侧额下回、双侧中央前回、左侧额上回、右侧额极)和左半球的其他区域,包括颞极、岛叶、壳核、角回和顶叶岛盖。在颞叶内侧(双侧杏仁核、左侧海马体、内嗅皮层和旁海马回)、视觉处理区域(双侧枕叶、右侧中颞叶)和其他区域(左侧眶额皮层、左侧岛叶、左侧壳核、左侧苍白球和左侧颞极)的编码和检索荟萃分析图谱中观察到相当大的重叠。当前的发现增加了对杏仁核、海马体和新皮层区域在成功编码和检索情绪情景记忆中的作用的理解,澄清并提供了该领域当前文献的重要总结,并对情绪情景记忆编码和检索的当前理论具有启示意义。

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