KLRB1基因的转录/表达作为人食管鳞状细胞癌的预后指标
Transcription/Expression of KLRB1 Gene as A Prognostic Indicator in Human Esophageal Squamous Cell Carcinoma.
作者信息
Zhang Guangwei, Liu Ying, Dong Fajin, Liu Xianming
机构信息
The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.
出版信息
Comb Chem High Throughput Screen. 2020;23(7):667-674. doi: 10.2174/1386207323666200517114154.
AIM AND OBJECTIVE
Esophageal squamous cell carcinoma (ESCC) is the most prevalent type of cancer with worldwide distribution and dismal prognosis despite ongoing efforts to improve treatment options. Therefore, it is essential to determine the prognostic factors for ESCC.
METHODS AND RESULTS
We determined KLRB1 to be a prognostic indicator of human ESCC. KLRB1 was expressed at low levels in ESCC patients. Based on the risk score, patients were divided into high and low-risk groups. High-risk patients showed a poor survival rate. The prediction model based on the N stage, sex, and KLRB1 was significantly better than that based on the N stage and sex. The modified prediction model showed a robust ROC curve with an AUC value of 0.973. The knockdown of KLRB1 inhibited the growth of human ESCC cells. KLRB1 regulated Akt, mTOR, p27, p38, NF-κB, Cyclin D1, and JNK signaling, which was consistent with the result of GSEA.
CONCLUSION
KLRB1 is a potential prognostic marker for human ESCC patients.
目的
食管鳞状细胞癌（ESCC）是全球分布最普遍的癌症类型，尽管不断努力改善治疗方案，但其预后仍不容乐观。因此，确定ESCC的预后因素至关重要。
方法与结果
我们确定KLRB1是人类ESCC的预后指标。KLRB1在ESCC患者中低表达。根据风险评分，将患者分为高风险组和低风险组。高风险患者的生存率较低。基于N分期、性别和KLRB1的预测模型明显优于基于N分期和性别的模型。改良后的预测模型显示出稳健的ROC曲线，AUC值为0.973。敲低KLRB1可抑制人类ESCC细胞的生长。KLRB1调节Akt、mTOR、p27、p38、NF-κB、细胞周期蛋白D1和JNK信号通路，这与GSEA结果一致。
结论
KLRB1是人类ESCC患者潜在的预后标志物。
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