Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Group of Experimental Biotherapy and Diagnostic, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow 119991, Russia.
Trends Cancer. 2020 Aug;6(8):660-676. doi: 10.1016/j.trecan.2020.04.007. Epub 2020 May 13.
Brain metastasis is an important cause of mortality in patients with cancer and represents the majority of all intracranial tumors. A key step during the metastatic journey of the cancer cell to the brain is the invasion through the blood-brain barrier (BBB). Nevertheless, the molecular mechanisms that govern this process remain unknown. The BBB has been blamed for limiting the access of therapeutic drugs to the brain, which provides a safe haven for cancer cells in the brain and confers poor prognosis for the patient. Here, we explore the genes that control the transmigration of metastatic cancer cells across the BBB, offering new targets for the development of gene and cell therapies against brain metastases.
脑转移是癌症患者死亡的一个重要原因，也是所有颅内肿瘤的主要类型。癌细胞转移到大脑的过程中，一个关键步骤是穿透血脑屏障（BBB）。然而，控制这一过程的分子机制尚不清楚。BBB 被指责限制了治疗性药物进入大脑，这为大脑中的癌细胞提供了一个安全的避难所，并导致患者预后不良。在这里，我们探讨了控制转移性癌细胞穿过 BBB 迁移的基因，为针对脑转移的基因和细胞治疗的发展提供了新的靶点。
