Wu Jianfen, Wu Haijian, Zhou Fengqi, Wang Yongjie, Wang Chun, Ji Jianxiong
Department of Cardiothoracic surgery, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Cancer Gene Ther. 2025 Jun 2. doi: 10.1038/s41417-025-00916-6.
Lung cancer is the most common primary tumor associated with brain metastases. Currently, the molecular mechanisms underlying the pathogenesis of lung cancer brain metastasis (LCBM) have not been fully elucidated and effective therapeutic strategies for treating this disease are still lacking. The blood-brain barrier (BBB) is a selectively permeable membrane and is crucial in maintaining brain homeostasis. Increasing evidence from clinical and pre-clinical studies indicated that metastatic circulating tumor cells from lung cancer can affect the cellular biology of BBB components, and destruct its integrity as well as function to penetrate the BBB to clone in the brain parenchyma, therein producing malignant secondary tumors. Therefore, in this review, we aim to discuss about the involvement of BBB alterations during the initiation of LCBM and the cellular and molecular mechanisms underlying. A better understanding of these pathophysiological processes may help open avenues to develop new therapeutic strategies to prevent or treat this notorious disease.
肺癌是与脑转移相关的最常见原发性肿瘤。目前，肺癌脑转移（LCBM）发病机制的分子机制尚未完全阐明，且仍缺乏治疗该疾病的有效策略。血脑屏障（BBB）是一种选择性渗透膜，对维持脑内稳态至关重要。临床和临床前研究的越来越多证据表明，肺癌转移性循环肿瘤细胞可影响血脑屏障成分的细胞生物学，破坏其完整性和功能，从而穿透血脑屏障在脑实质中克隆，进而产生恶性继发性肿瘤。因此，在本综述中，我们旨在讨论血脑屏障改变在肺癌脑转移起始过程中的作用及其潜在的细胞和分子机制。更好地理解这些病理生理过程可能有助于开辟新的治疗策略开发途径，以预防或治疗这种难治性疾病。
