Center for Health + Technology, University of Rochester Medical Center, Rochester, NY, USA.
Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.
J Parkinsons Dis. 2020;10(3):1239-1243. doi: 10.3233/JPD-201973.
Parkinson's disease (PD) patients experience a range of non-motor symptoms that are believed to be related to disease pathophysiology, many of which are treatable by medications. Among newly-diagnosed PD participants in the Parkinson's Progression Markers Initiative study, we describe (1) the frequency of medication use for common non-motor symptoms, and (2) when non-motor symptomatic treatment was initiated relative to PD diagnosis. Non-motor medication use was reported by 73% of participants, most commonly for depression, constipation, and anxiety. Treatment of some non-motor symptoms, notably depression, antedated diagnosis. These data may be useful for studies of non-motor symptoms in PD.
帕金森病（PD）患者经历一系列被认为与疾病病理生理学相关的非运动症状，其中许多症状可以通过药物治疗。在帕金森进展标志物倡议研究中，我们描述了（1）新发 PD 患者使用药物治疗常见非运动症状的频率，以及（2）非运动症状治疗相对于 PD 诊断的起始时间。73%的参与者报告了非运动药物的使用，最常见的是用于治疗抑郁、便秘和焦虑。一些非运动症状的治疗，特别是抑郁，早于诊断。这些数据可能对 PD 中非运动症状的研究有用。
