在 1 或 2 个周期的计划卵母细胞冷冻保存中实现 50%、60%或 70%估计活产率阈值的可能性。
Likelihood of achieving a 50%, 60%, or 70% estimated live birth rate threshold with 1 or 2 cycles of planned oocyte cryopreservation.
机构信息
Extend Fertility Medical Practice - Center for Fertility Research and Education, 200 West 57th Street - Suite 1101, New York, NY, 10019, USA.
出版信息
J Assist Reprod Genet. 2020 Jul;37(7):1637-1643. doi: 10.1007/s10815-020-01791-w. Epub 2020 May 16.
PURPOSE
To characterize the likelihood of cryopreserving enough oocytes for 50%, 60%, or 70% estimated live birth rate (eLBR) with 1-2 planned oocyte cryopreservation (Pl-OC) cycles.
METHODS
We performed a retrospective cohort study utilizing all patients completing ≥ 1 Pl-OC cycle from 2016 to 2018 at a large single-center OC program. Subjects were categorized by age at retrieval and number of cycles. We extrapolated age-based oocyte thresholds for 50%, 60%, or 70% eLBR from previously published data. We calculated the proportion of subjects overall, and for each age group, whose number of frozen oocytes was greater than or equal to their age-based threshold for a 50%, 60%, or 70% eLBR after 1 and 2 cycles. OR for 60% eLBR with one cycle was calculated for age and AMH cutoff values and corroborated with logistic regression.
RESULTS
A total of 1241 subjects, completing 1799 Pl-OC cycles, were included. With one cycle, 66% (819/1241) achieved ≥ 50% eLBR and 51% (634/1241) achieved 70% eLBR. With two cycles, 79.6% (988/1241) attained ≥ 50% eLBR and 65.5% (813/1241) achieved 70% eLBR. Achieving 50%, 60%, or 70% eLBR with 1-2 cycles was significantly associated with both age (p < 0.001) and AMH (p < 0.001). Age < 37.5 and AMH > 1.995 were independently associated with attaining 60% eLBR with one cycle (age: OR 13.73; 95%CI 9.16-20.57, p < 0.001; AMH: OR 7.32; 95% CI 5.50-9.76, p < 0.001).
CONCLUSIONS
Younger age and higher AMH were associated with achieving 50%, 60%, or 70% eLBR thresholds with Pl-OC. Nevertheless, almost all subjects were successfully able to preserve enough oocytes for ≥ 50% eLBR in 1-2 cycles.
目的
通过 1-2 次计划的卵母细胞冷冻保存 (Pl-OC) 周期，确定冷冻保存足够数量的卵母细胞以实现 50%、60%或 70%估计活产率 (eLBR) 的可能性。
方法
我们利用 2016 年至 2018 年在一家大型单中心 OC 项目中完成≥1 次 Pl-OC 周期的所有患者进行了回顾性队列研究。受试者根据取卵时的年龄和周期数进行分类。我们从之前发表的数据中推断出基于年龄的 50%、60%或 70%eLBR 的卵母细胞阈值。我们计算了在 1 次和 2 次周期后，总体以及每个年龄组中，冷冻卵母细胞数量超过或等于其 50%、60%或 70%eLBR 年龄阈值的受试者比例。对于 1 个周期的 60%eLBR 的 OR，我们计算了年龄和 AMH 截止值的比值，并与逻辑回归进行了验证。
结果
共纳入 1241 名受试者，完成了 1799 次 Pl-OC 周期。1 次周期后，66%（819/1241）达到≥50%eLBR，51%（634/1241）达到 70%eLBR。2 次周期后，79.6%（988/1241）达到≥50%eLBR，65.5%（813/1241）达到 70%eLBR。1-2 次周期达到 50%、60%或 70%eLBR 与年龄（p<0.001）和 AMH（p<0.001）显著相关。年龄<37.5 岁和 AMH>1.995 与 1 个周期内达到 60%eLBR 独立相关（年龄：OR 13.73；95%CI 9.16-20.57，p<0.001；AMH：OR 7.32；95%CI 5.50-9.76，p<0.001）。
结论
年轻的年龄和更高的 AMH 与 Pl-OC 实现 50%、60%或 70%eLBR 阈值相关。然而，几乎所有患者都能够在 1-2 次周期内成功保存足够数量的卵母细胞以实现≥50%eLBR。
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