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长角血蜱唾液腺退化过程中蛋白质磷酸化的变化

Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis.

作者信息

Xiao Qi, Hu Yuhong, Yang Xiaohong, Tang Jianna, Wang Xiaoshuang, Xue Xiaomin, Li Mengxue, Wang Minjing, Zhao Yinan, Liu Jingze, Wang Hui

机构信息

Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei 050024, PR China.

Instrumental Analysis Center, Hebei Normal University, Shijiazhuang, Hebei 050024, PR China.

出版信息

Korean J Parasitol. 2020 Apr;58(2):161-171. doi: 10.3347/kjp.2020.58.2.161. Epub 2020 Apr 30.

DOI:10.3347/kjp.2020.58.2.161
PMID:32418385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7231830/
Abstract

The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study, data-independent acquisition quantitative proteomics was used to study changes in the phosphorylation modification of proteins during salivary gland degeneration in Haemaphysalis longicornis. In this quantitative study, 400 phosphorylated proteins and 850 phosphorylation modification sites were identified. Trough RNA interference experiments, we found that among the proteins with changes in phosphorylation, apoptosis-promoting Hippo protein played a role in salivary gland degeneration.

摘要

蜱虫从宿主身上吸食大量血液，并将病原体传播给受害者。唾液腺在吸血过程中起着重要作用。当雌蜱接近饱食时，唾液腺逐渐失去功能并开始迅速退化。在本研究中，采用数据非依赖采集定量蛋白质组学方法研究长角血蜱唾液腺退化过程中蛋白质磷酸化修饰的变化。在这项定量研究中，鉴定出400种磷酸化蛋白和850个磷酸化修饰位点。通过RNA干扰实验，我们发现在磷酸化发生变化的蛋白质中，促凋亡的Hippo蛋白在唾液腺退化中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/7231830/ac7134219dd4/kjp-58-2-161f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/7231830/283513263c35/kjp-58-2-161f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/7231830/223efc859f0f/kjp-58-2-161f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/7231830/1181f9e5f467/kjp-58-2-161f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/7231830/526cd76a55d1/kjp-58-2-161f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/7231830/ac7134219dd4/kjp-58-2-161f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/7231830/283513263c35/kjp-58-2-161f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/7231830/223efc859f0f/kjp-58-2-161f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/7231830/1181f9e5f467/kjp-58-2-161f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/7231830/526cd76a55d1/kjp-58-2-161f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/7231830/ac7134219dd4/kjp-58-2-161f5.jpg

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Front Physiol. 2019 May 3;10:529. doi: 10.3389/fphys.2019.00529. eCollection 2019.
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