Campoli Caterina, Ferraro Sara, Salfi Nunzio, Coladonato Simona, Morelli Maria Cristina, Giannella Maddalena, Ambretti Simone, Viale Pier Luigi, Cricca Monica
Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant'Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, Bologna, Italy.
Operative Unit of Clinical Microbiology, Policlinico Sant'Orsola Malpighi, Via Massarenti 9, 40138, Bologna, Italy.
Med Mycol Case Rep. 2020 May 4;28:42-45. doi: 10.1016/j.mmcr.2020.04.007. eCollection 2020 Jun.
Fungal infections are rare in the general population but are an emerging cause of disease in immunosuppressed patients, especially solid organ transplant recipients. Here, we report the case of a female Caucasian liver transplant patient who developed pulmonary nocardiosis two months after an episode of liver rejection. At the time of lung nocardiosis, she was being treated with tacrolimus and corticosteroids and suffered from diffuse papular skin lesions. She was initially suspected of having a cutaneous nocardial infection but culture examination revealed the presence of a dematiaceous fungus; . The prompt identification of the fungus and administration of oral Voriconazole resolved the skin infection with complete remission.
真菌感染在普通人群中较为罕见,但在免疫抑制患者中,尤其是实体器官移植受者中,正成为一种新出现的致病原因。在此,我们报告一例白种女性肝移植患者的病例,该患者在发生肝排斥反应两个月后出现了肺部诺卡菌病。在发生肺部诺卡菌病时,她正在接受他克莫司和皮质类固醇治疗,且患有弥漫性丘疹性皮肤病变。她最初被怀疑患有皮肤诺卡菌感染,但培养检查显示存在一种暗色真菌。对该真菌的迅速识别以及口服伏立康唑的给药使皮肤感染得到解决并完全缓解。