Department of Biology, University of Wisconsin Oshkosh, Oshkosh, Wisconsin, US.
Department of Chemistry, University of Wisconsin Oshkosh, Oshkosh, Wisconsin, US.
J Appl Toxicol. 2020 Oct;40(10):1384-1395. doi: 10.1002/jat.3991. Epub 2020 May 18.
Human exposure to a wide variety of engineered nanoparticles (NPs) is on the rise and use in common food additives increases gastrointestinal (GI) exposure. Host health is intricately linked to the GI microbiome and immune response. Perturbations in the microbiota can affect energy harvest, trigger inflammation and alter the mucosal barrier leading to various disease states such as obesity and inflammatory bowel diseases. We hypothesized that single high-dose titanium dioxide (TiO ) NP exposure in mice would lead to dysbiosis and stimulate mucus production and local immune populations. Juvenile mice (9-10 weeks) were gavaged with 1 g/kg TiO NPs and examined for changes in mucosa-associated bacteria abundance, inflammatory cytokines, mucin expression and body mass. Our data provide support that TiO NP ingestion alters the GI microbiota and host defenses promoting metabolic disruption and subsequently weight gain in mice.
人类接触到的各种工程纳米粒子（NPs）的数量正在增加，而在常见食品添加剂中的使用则增加了胃肠道（GI）的暴露。宿主健康与 GI 微生物组和免疫反应密切相关。微生物群的紊乱会影响能量的获取，引发炎症，并改变粘膜屏障，导致各种疾病状态，如肥胖和炎症性肠病。我们假设，单次高剂量二氧化钛（TiO ）NP 暴露在小鼠中会导致菌群失调，并刺激粘液的产生和局部免疫细胞的产生。幼年小鼠（9-10 周）经灌胃给予 1 g/kg TiO NPs，并观察粘膜相关细菌丰度、炎症细胞因子、粘蛋白表达和体重的变化。我们的数据支持 TiO NP 摄入会改变 GI 微生物群和宿主防御，从而促进代谢紊乱，并随后导致小鼠体重增加。
