Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Skromna 8, Lublin, Poland.
Biol Trace Elem Res. 2021 Dec;199(12):4458-4465. doi: 10.1007/s12011-021-02578-5. Epub 2021 Jan 14.
The recent years have seen a significant interest in the applications of nanotechnology in various facets of our lives. Due to their increasingly widespread use, human exposure to nanoparticles (NPs) is fast becoming unavoidable. Among the wide group of nanoparticles currently employed in industry, titanium dioxide nanoparticles, TiO NPs, are particularly popular. Due to its white colour, TiO is widely used as a whitening food additive (E 171). Yet, there have been few studies aimed at determining its direct impact on bacteria, while the available data suggest that TiO NPs may influence microbiota causing problems such as inflammatory bowel disease, obesity, or immunological disorders. Indeed, there are increasing concerns that its presence may lead to intestinal barrier impairment, including dysbiosis of intestinal microbiota. This article aims to present an overview of studies conducted to date with regard to the impact of TiO NPs on human microbiota as well as factors that can affect the same. Such information is necessary if we are to conclusively determine the potential toxicity of inorganic nanoparticles.
近年来，人们对纳米技术在我们生活的各个方面的应用产生了浓厚的兴趣。由于纳米材料的使用越来越广泛，人类接触纳米颗粒（NPs）的情况也变得越来越难以避免。在目前广泛应用于工业领域的众多纳米颗粒中，二氧化钛纳米颗粒（TiO NPs）尤为受欢迎。由于其白色外观，TiO 被广泛用作增白食品添加剂（E171）。然而，目前针对其对细菌的直接影响的研究较少，而现有数据表明，TiO NPs 可能会影响微生物群落，导致炎症性肠病、肥胖或免疫紊乱等问题。事实上，人们越来越担心其存在可能导致肠道屏障受损，包括肠道微生物群落的失调。本文旨在概述迄今为止关于 TiO NPs 对人类微生物群影响的研究，以及可能影响其的因素。如果我们要确定无机纳米颗粒的潜在毒性，那么这些信息是必要的。
