National Institute of Laser Enhanced Sciences, Cairo University, Cairo, Egypt.
Faculty of Medicine, Dermatology Department, Cairo University, Cairo, Egypt.
J Dermatolog Treat. 2022 Feb;33(1):555-559. doi: 10.1080/09546634.2020.1771259. Epub 2021 Jun 4.
Although there are different treatment modalities of melasma, it remains a challenging problem. Erbium-YAG laser proved its efficacy in melasma improvement with minimal downtime. Tranexamic acid (TA) is a new promising treatment of melasma.
The first objective is to compare between the efficacy of intradermal injection of TA and Erbium-YAG laser in the treatment of melasma. The second objective is to use the dermoscope as an objective evaluation method.
A split face study was conducted on 28 patients. One side of the face received intradermal TA injection. The other side was treated with laser. Melasma Area and Severity Index (MASI) and the dermoscope were used for evaluation of treatment.
The MASI scores showed a significant decrease in TA treated side. The dermoscope assessment showed no significant difference in both treatment modalities.
A promising results were obtained by both intradermal TA and Erbium:YAG laser; however, the TA yields a higher patient satisfaction because of its high efficiency and low cost.
尽管有不同的治疗黄褐斑的方法，但它仍然是一个具有挑战性的问题。铒雅铬激光（Erbium-YAG laser）已被证明在改善黄褐斑方面具有疗效，且恢复期较短。氨甲环酸（tranexamic acid，TA）是治疗黄褐斑的一种有前途的新方法。
第一个目的是比较真皮内注射 TA 和铒雅铬激光治疗黄褐斑的疗效。第二个目的是使用皮肤镜作为客观评估方法。
对 28 例患者进行了半脸研究。一侧面部接受真皮内 TA 注射，另一侧用激光治疗。使用黄褐斑面积和严重程度指数（MASI）和皮肤镜进行治疗评估。
MASI 评分显示 TA 治疗侧显著下降。皮肤镜评估显示两种治疗方法之间无显著差异。
真皮内 TA 和铒雅铬激光均取得了有前景的效果；然而，由于 TA 效率高、成本低，患者满意度更高。
