Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy University .
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy University.
Acta Biomed. 2020 May 11;91(2):350-355. doi: 10.23750/abm.v91i2.9641.
Allergic rhinitis and asthma are closely linked. A progression from rhinitis to overt asthma is common. FEF25-75 is a spirometry parameter that could reflect small airways patency and could reliably predict early bronchial involvement in allergic rhinitis patients. MEF50 very strongly correlates with FEF25-75. The aim of this study was to evaluate possible spirometry change in two groups of children suffering from AR over time. The first group took a course of a nutraceutical (Lertal®) before the observation (active group, AG); a second one was considered as control (control group, CG). The children were visited at baseline, at the end of the nutraceutical course, and after 1 year. FEV1, FVC, and MEF50 were the primary outcomes. After one year, children in AG had significantly higher MEF50 than CG children (p=0.009). In conclusion, the present study showed that a course with a multicomponent nutraceutical could prevent the MEF50 decline in children with allergic rhinoconjunctivitis.
变应性鼻炎和哮喘密切相关。从鼻炎发展为明显哮喘是常见的。FEF25-75 是一项肺量测定参数，可反映小气道通畅性，并能可靠地预测变应性鼻炎患者早期支气管受累。MEF50 与 FEF25-75 高度相关。本研究旨在评估两组变应性鼻炎患儿随时间推移的可能肺量测定变化。第一组在观察前服用了营养补充剂（Lertal®）（观察组，AG）；另一组被认为是对照组（对照组，CG）。患儿在基线、营养补充剂疗程结束和 1 年后接受访视。FEV1、FVC 和 MEF50 是主要结果。一年后，AG 组患儿的 MEF50 显著高于 CG 组患儿（p=0.009）。总之，本研究表明，使用多成分营养补充剂治疗可预防变应性鼻结膜炎患儿 MEF50 下降。
