Allergy Center, Istituto Giannina Gaslini, Genoa, Italy.
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy University .
Acta Biomed. 2020 May 11;91(2):356-359. doi: 10.23750/abm.v91i2.9719.
Antihistamines are the cornerstone treatment of allergic rhinitis (AR). To quantify the antihistaminic consume is particularly relevant in clinical practice, since a remarkable use is usually associated with severe symptoms. The aim of the study was to measure the use of antihistamines in two groups of children suffering from AR. The first group took a course of a nutraceutical (Lertal®) before the observation (active group, AG); a second one was considered as control (control group, CG). Both groups took antihistamines on demand. The children were visited at baseline and after 1 year. The number of days of antihistaminic use was the primary outcome. Children in AG had a significant reduced number of antihistamines use in comparison with CG (p=0.008). In conclusion, the current study showed that a course with a multicomponent nutraceutical could reduce the use of symptomatic antihistamines in children with allergic rhinoconjuncti- vitis.
抗组胺药是治疗过敏性鼻炎(AR)的基石。在临床实践中,量化抗组胺药物的使用量尤为重要,因为大量使用通常与严重症状相关。本研究旨在测量两组患有 AR 的儿童使用抗组胺药的情况。第一组在观察前服用了一个营养保健品(Lertal®)(实验组,AG);另一组作为对照组(对照组,CG)。两组均按需服用抗组胺药。在基线和 1 年后对儿童进行了随访。抗组胺药使用天数是主要结局。与 CG 相比,AG 组儿童使用抗组胺药的天数显著减少(p=0.008)。综上所述,本研究表明,使用多组分营养保健品进行疗程治疗可能会减少患有过敏性鼻结膜炎的儿童对对症性抗组胺药的使用。