膳食脂肪酸摄入模式与韩国成年人高 LDL 胆固醇血症风险的关联。

Association of Dietary Fatty Acid Consumption Patterns with Risk of Hyper-LDL Cholesterolemiain Korean Adults.

机构信息

Department of Public Health Science, Graduate School of Public Health, Seoul National University,Seoul 08826, Korea.

Institute of Health and Environment, Seoul National University, Seoul 08826, Korea.

出版信息

Nutrients. 2020 May 14;12(5):1412. doi: 10.3390/nu12051412.

DOI:10.3390/nu12051412

PMID:32422908

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7284755/

Abstract

This study aimed to identify the association between the risk of hyper-LDL cholesterolemia (hyper-LDLC) and fatty acid consumption patterns (FACPs) using the data from the Korean Genome and Epidemiology Study (KoGES) prospective cohort. A total of 6542 middle-aged Korean adults were included in the analysis. Four FACPs were identified through principal component analysis of the reported intakes of 34 fatty acids (FAs): "long-chain FA pattern"; "short & medium-chain saturated fatty acid (SFA) pattern"; "n-3 polyunsaturated fatty acid (PUFA) pattern"; and "long-chain SFA pattern". The "long-chain SFA pattern" lowered the risk of hyper-LDLC (relative risk (RR), 0.82; 95% confidence interval (CI), 0.72-0.94; p for trend, 0.004) and the "short & medium-chain SFA pattern" increased the risk of hyper-LDLC (RR, 1.17; 95% CI, 1.03-1.32; p for trend = 0.004). In sex-stratified analyses, the associations of the "long-chain SFA pattern" (RR, 0.73; 95% CI, 0.58-0.93; p for trend = 0.007) and the "short & medium-chain SFA pattern" (RR, 1.34; 95% CI, 1.07-1.69; p for trend = 0.003) with the hyper-LDLC risk were observed only in men, but not in women. These results suggest that FACPs with a high intake of long-chain SFA or a low intake of short and medium-chain SFA may protect Korean adults from hyper-LDLC.

摘要

本研究旨在利用韩国基因组与流行病学研究（KoGES）前瞻性队列的数据，确定高 LDL 胆固醇血症（hyper-LDLC）风险与脂肪酸消费模式（FACPs）之间的关联。共纳入 6542 名中年韩国成年人进行分析。通过对报告的 34 种脂肪酸（FAs）摄入量进行主成分分析，确定了四种 FACPs：“长链 FA 模式”；“短链和中链饱和脂肪酸（SFA）模式”；“n-3 多不饱和脂肪酸（PUFA）模式”；和“长链 SFA 模式”。“长链 SFA 模式”降低了 hyper-LDLC 的风险（相对风险（RR），0.82；95%置信区间（CI），0.72-0.94；p 趋势=0.004），“短链和中链 SFA 模式”增加了 hyper-LDLC 的风险（RR，1.17；95%CI，1.03-1.32；p 趋势=0.004）。在性别分层分析中，仅在男性中观察到“长链 SFA 模式”（RR，0.73；95%CI，0.58-0.93；p 趋势=0.007）和“短链和中链 SFA 模式”（RR，1.34；95%CI，1.07-1.69；p 趋势=0.003）与 hyper-LDLC 风险之间存在关联，但在女性中不存在。这些结果表明，高摄入长链 SFA 或低摄入短链和中链 SFA 的 FACPs 可能会保护韩国成年人免受 hyper-LDLC 的影响。