• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

阿尔茨海默病模型中长链非编码RNA和信使RNA表达的微阵列分析

Microarray Profile of Long Noncoding RNA and Messenger RNA Expression in a Model of Alzheimer's Disease.

作者信息

Wang Linlin, Zeng Li, Jiang Hailun, Li Zhuorong, Liu Rui

机构信息

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

出版信息

Life (Basel). 2020 May 14;10(5):64. doi: 10.3390/life10050064.

DOI:10.3390/life10050064
PMID:32423012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7281340/
Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by a deficiency in cognitive skills. Although long noncoding RNAs (lncRNAs) have been proposed as associated with AD, the aberrant lncRNAs expression and the co-expression of lncRNAs-mRNAs network in AD remains unclear. Therefore, in this study, lncRNA microarray was performed on the brain of APP/PS1 mice at different age, widely used as an AD mouse model, and on age-matched wide-type controls. Our results identified a total of 3306 lncRNAs and 2458 mRNAs as aberrantly expressed among AD mice at different age and their age-matched control. Gene Ontology and pathway analysis of the AD-related lncRNAs and mRNAs indicated that neuroinflammation-related and synaptic transmission signaling pathways represented the main enriched pathways. An lncRNA-mRNA-miRNA network between the differentially expressed transcripts was constructed. Moreover, an mRNA-miRNA network between both significantly dysregulated and highly conserved genes was also constructed, and among this network, the IGF1, P2RX7, TSPO, SERPINE1, EGFR, HMOX1, and NFE212 genes were predicted to play a role in the development of AD. In conclusion, this study illustrated the prognostic value of lncRNAs and mRNAs associated to AD pathology by microarray analysis and might provide potential novel biomarkers in the diagnosis and treatment of AD.

摘要

阿尔茨海默病（AD）是一种以认知技能缺陷为特征的进行性神经退行性疾病。尽管长链非编码RNA（lncRNAs）已被提出与AD相关，但AD中lncRNAs的异常表达以及lncRNAs - mRNAs网络的共表达仍不清楚。因此，在本研究中，对广泛用作AD小鼠模型的不同年龄的APP/PS1小鼠的大脑以及年龄匹配的野生型对照进行了lncRNA微阵列分析。我们的结果在不同年龄的AD小鼠及其年龄匹配的对照中总共鉴定出3306个lncRNAs和2458个mRNA为异常表达。对与AD相关的lncRNAs和mRNAs进行基因本体论和通路分析表明，神经炎症相关和突触传递信号通路是主要的富集通路。构建了差异表达转录本之间的lncRNA - mRNA - miRNA网络。此外，还构建了显著失调和高度保守基因之间的mRNA - miRNA网络，在这个网络中，IGF1、P2RX7、TSPO、SERPINE1、EGFR、HMOX1和NFE212基因被预测在AD的发展中起作用。总之，本研究通过微阵列分析阐明了与AD病理相关的lncRNAs和mRNAs的预后价值，并可能为AD的诊断和治疗提供潜在的新型生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/c070e242002a/life-10-00064-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/202c4a3fe431/life-10-00064-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/c1dbe73ee22b/life-10-00064-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/a5f7afd4d888/life-10-00064-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/aaf1428dca26/life-10-00064-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/ec7c35ad64d1/life-10-00064-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/a166b3abff1c/life-10-00064-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/66e7928c6a88/life-10-00064-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/d2550d55bfff/life-10-00064-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/ac2fd5253342/life-10-00064-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/a3a84b121353/life-10-00064-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/a20a03738897/life-10-00064-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/90b4c0bc8e0e/life-10-00064-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/c070e242002a/life-10-00064-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/202c4a3fe431/life-10-00064-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/c1dbe73ee22b/life-10-00064-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/a5f7afd4d888/life-10-00064-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/aaf1428dca26/life-10-00064-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/ec7c35ad64d1/life-10-00064-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/a166b3abff1c/life-10-00064-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/66e7928c6a88/life-10-00064-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/d2550d55bfff/life-10-00064-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/ac2fd5253342/life-10-00064-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/a3a84b121353/life-10-00064-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/a20a03738897/life-10-00064-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/90b4c0bc8e0e/life-10-00064-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1756/7281340/c070e242002a/life-10-00064-g013.jpg

相似文献

1
Microarray Profile of Long Noncoding RNA and Messenger RNA Expression in a Model of Alzheimer's Disease.阿尔茨海默病模型中长链非编码RNA和信使RNA表达的微阵列分析
Life (Basel). 2020 May 14;10(5):64. doi: 10.3390/life10050064.
2
In-depth transcriptomic analyses of LncRNA and mRNA expression in the hippocampus of APP/PS1 mice by Danggui-Shaoyao-San.当归芍药散对 APP/PS1 小鼠海马组织中长链非编码 RNA 和信使 RNA 表达的深入转录组分析。
Aging (Albany NY). 2020 Nov 18;12(23):23945-23959. doi: 10.18632/aging.104068.
3
Comprehensive Analysis of Long Non-Coding RNAs N4-Acetylcytidine in Alzheimer's Disease Mice Model Using High-Throughput Sequencing.利用高通量测序对阿尔茨海默病小鼠模型中长链非编码RNA N4-乙酰胞苷进行综合分析
J Alzheimers Dis. 2022;90(4):1659-1675. doi: 10.3233/JAD-220564.
4
Identifying lncRNA-miRNA-mRNA networks to investigate Alzheimer's disease pathogenesis and therapy strategy.鉴定 lncRNA-miRNA-mRNA 网络，以研究阿尔茨海默病的发病机制和治疗策略。
Aging (Albany NY). 2020 Feb 7;12(3):2897-2920. doi: 10.18632/aging.102785.
5
Identification of a lncRNA/circRNA-miRNA-mRNA ceRNA Network in Alzheimer's Disease.鉴定阿尔茨海默病中的 lncRNA/circRNA-miRNA-mRNA ceRNA 网络。
J Integr Neurosci. 2023 Oct 17;22(6):136. doi: 10.31083/j.jin2206136.
6
Differential Expression of Long Noncoding RNAs in Murine Myoblasts After Short Hairpin RNA-Mediated Dysferlin Silencing In Vitro: Microarray Profiling.短发夹RNA介导的dysferlin体外沉默后小鼠成肌细胞中长链非编码RNA的差异表达：微阵列分析
JMIR Bioinform Biotechnol. 2022 Jun 17;3(1):e33186. doi: 10.2196/33186.
7
Bioinformatics and co-expression network analysis of differentially expressed lncRNAs and mRNAs in hippocampus of APP/PS1 transgenic mice with Alzheimer disease.阿尔茨海默病APP/PS1转基因小鼠海马中差异表达的lncRNA和mRNA的生物信息学及共表达网络分析
Am J Transl Res. 2017 Mar 15;9(3):1381-1391. eCollection 2017.
8
Altered Expression of Long Non-coding RNAs in Peripheral Blood Mononuclear Cells of Patients with Alzheimer's Disease.阿尔茨海默病患者外周血单个核细胞中长非编码 RNA 的表达改变。
Mol Neurobiol. 2020 Dec;57(12):5352-5361. doi: 10.1007/s12035-020-02106-x. Epub 2020 Sep 3.
9
Expression Profiles of Long Noncoding RNAs in Intranasal LPS-Mediated Alzheimer's Disease Model in Mice.在小鼠内嗅 LPS 介导的阿尔茨海默病模型中长非编码 RNA 的表达谱。
Biomed Res Int. 2019 Jan 21;2019:9642589. doi: 10.1155/2019/9642589. eCollection 2019.
10
Long noncoding RNA and messenger RNA abnormalities in pediatric sepsis: a preliminary study.儿童脓毒症中长链非编码RNA和信使RNA异常：一项初步研究。
BMC Med Genomics. 2020 Mar 10;13(1):36. doi: 10.1186/s12920-020-0698-x.

引用本文的文献

1
Insulin-Like Growth Factor Signaling in Alzheimer's Disease: Pathophysiology and Therapeutic Strategies.阿尔茨海默病中的胰岛素样生长因子信号传导：病理生理学与治疗策略
Mol Neurobiol. 2025 Mar;62(3):3195-3225. doi: 10.1007/s12035-024-04457-1. Epub 2024 Sep 6.
2
Correction: Wang et al. Microarray Profile of Long Noncoding RNA and Messenger RNA Expression in a Model of Alzheimer's Disease. 2020, , 64.更正：王等人。阿尔茨海默病模型中长链非编码RNA和信使RNA表达的微阵列分析。2020年，，64。 （你提供的原文中存在一些格式不清晰的地方，可能会影响准确理解，以上是尽量按照现有内容翻译的结果。）
Life (Basel). 2024 Feb 29;14(3):326. doi: 10.3390/life14030326.
3
Sex- and region-specific cortical and hippocampal whole genome transcriptome profiles from control and APP/PS1 Alzheimer's disease mice.

本文引用的文献

1
Exploring the Promise of Targeting Ubiquitin-Proteasome System to Combat Alzheimer's Disease.探索靶向泛素-蛋白酶体系统治疗阿尔茨海默病的前景。
Neurotox Res. 2020 Jun;38(1):8-17. doi: 10.1007/s12640-020-00185-1. Epub 2020 Mar 9.
2
Toxic tau: structural origins of tau aggregation in Alzheimer's disease.毒性tau蛋白：阿尔茨海默病中tau蛋白聚集的结构起源
Neural Regen Res. 2020 Aug;15(8):1417-1420. doi: 10.4103/1673-5374.274329.
3
Editorial: The Alzheimer's Disease Challenge.社论：阿尔茨海默病挑战
来自对照和 APP/PS1 阿尔茨海默病小鼠的性别和区域特异性皮质和海马全基因组转录组图谱。
PLoS One. 2024 Feb 7;19(2):e0296959. doi: 10.1371/journal.pone.0296959. eCollection 2024.
4
Construction of lncRNA-ceRNA Networks to Reveal the Potential Role of Lfng/Notch1 Signaling Pathway in Alzheimer's Disease.构建长链非编码RNA-竞争性内源RNA网络以揭示Lfng/Notch1信号通路在阿尔茨海默病中的潜在作用
Curr Alzheimer Res. 2022;19(11):772-784. doi: 10.2174/1567205020666221130090103.
5
Assessing spermatozoal small ribonucleic acids and their relationship to blastocyst development in idiopathic infertile males.评估不明原因不育男性精子中的小核糖核酸及其与囊胚发育的关系。
Sci Rep. 2022 Nov 21;12(1):20010. doi: 10.1038/s41598-022-24568-w.
6
Long Non-Coding RNAs, Extracellular Vesicles and Inflammation in Alzheimer's Disease.长非编码 RNA、细胞外囊泡与阿尔茨海默病中的炎症反应
Int J Mol Sci. 2022 Oct 29;23(21):13171. doi: 10.3390/ijms232113171.
7
miR-23b-3p rescues cognition in Alzheimer's disease by reducing tau phosphorylation and apoptosis via GSK-3β signaling pathways.微小RNA-23b-3p通过糖原合酶激酶-3β信号通路减少tau蛋白磷酸化和细胞凋亡，从而挽救阿尔茨海默病中的认知功能。
Mol Ther Nucleic Acids. 2022 Apr 18;28:539-557. doi: 10.1016/j.omtn.2022.04.008. eCollection 2022 Jun 14.
8
Nutrigenomic Studies on the Ameliorative Effect of Enzyme-Digested Phycocyanin in Alzheimer's Disease Model Mice.藻蓝蛋白酶解物对阿尔茨海默病模型小鼠的改善作用的营养基因组学研究。
Nutrients. 2021 Dec 10;13(12):4431. doi: 10.3390/nu13124431.
Front Neurosci. 2019 Jul 24;13:768. doi: 10.3389/fnins.2019.00768. eCollection 2019.
4
Autophagic dysfunction in Alzheimer's disease: Cellular and molecular mechanistic approaches to halt Alzheimer's pathogenesis.阿尔茨海默病中的自噬功能障碍：阻止阿尔茨海默病发病机制的细胞和分子机制方法。
J Cell Physiol. 2019 Jun;234(6):8094-8112. doi: 10.1002/jcp.27588. Epub 2018 Oct 26.
5
Multifaceted assessment of the APP/PS1 mouse model for Alzheimer's disease: Applying MRS, DTI, and ASL.阿尔茨海默病 APP/PS1 小鼠模型的多方面评估：应用 MRS、DTI 和 ASL。
Brain Res. 2018 Nov 1;1698:114-120. doi: 10.1016/j.brainres.2018.08.001. Epub 2018 Aug 3.
6
APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis.载脂蛋白 E 与阿尔茨海默病：越来越多的证据表明，针对载脂蛋白 E4 可能有助于对抗阿尔茨海默病的发病机制。
Mol Neurobiol. 2019 Apr;56(4):2450-2465. doi: 10.1007/s12035-018-1237-z. Epub 2018 Jul 21.
7
Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress.生长因子和神经球蛋白在星形胶质细胞对抗神经变性和氧化应激中的保护作用。
Mol Neurobiol. 2019 Apr;56(4):2339-2351. doi: 10.1007/s12035-018-1203-9. Epub 2018 Jul 7.
8
Identification of the biological affection of long noncoding RNA BC200 in Alzheimer's disease.长链非编码RNA BC200在阿尔茨海默病中的生物学作用鉴定
Neuroreport. 2018 Sep 5;29(13):1061-1067. doi: 10.1097/WNR.0000000000001057.
9
Insulin-like Growth Factor 1 (IGF-1) as a marker of cognitive decline in normal ageing: A review.胰岛素样生长因子 1（IGF-1）作为正常衰老认知能力下降的标志物：综述。
Ageing Res Rev. 2018 Mar;42:14-27. doi: 10.1016/j.arr.2017.12.002. Epub 2017 Dec 9.
10
Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer's Disease.阿尔茨海默病转基因小鼠模型中通过微阵列分析大脑中的 microRNA。
Biomed Res Int. 2017;2017:8030369. doi: 10.1155/2017/8030369. Epub 2017 Sep 19.