Department Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, TX 77843, USA.
Chem Soc Rev. 2020 Jun 7;49(11):3315-3347. doi: 10.1039/c8cs00916c. Epub 2020 May 19.
The advent of nanotechnology, and the need to understand the chemical composition at the nanoscale, has stimulated the convergence of IR and Raman spectroscopy with scanning probe methods, resulting in new nanospectroscopy paradigms. Here we review two such methods, namely photothermal induced resonance (PTIR), also known as AFM-IR and tip-enhanced Raman spectroscopy (TERS). AFM-IR and TERS fundamentals will be reviewed in detail together with their recent crucial advances. The most recent applications, now spanning across materials science, nanotechnology, biology, medicine, geology, optics, catalysis, art conservation and other fields are also discussed. Even though AFM-IR and TERS have developed independently and have initially targeted different applications, rapid innovation in the last 5 years has pushed the performance of these, in principle spectroscopically complimentary, techniques well beyond initial expectations, thus opening new opportunities for their convergence. Therefore, subtle differences and complementarity will be highlighted together with emerging trends and opportunities.
纳米技术的出现以及对纳米尺度化学组成理解的需求，促使红外（IR）和拉曼（Raman）光谱学与扫描探针方法融合，产生了新的纳米光谱学范例。在这里，我们回顾了两种这样的方法，即光热诱导共振（PTIR），也称为原子力显微镜-IR（AFM-IR）和尖端增强拉曼光谱（TERS）。我们将详细回顾 AFM-IR 和 TERS 的基本原理及其最近的关键进展。还讨论了最近的应用，现在横跨材料科学、纳米技术、生物学、医学、地质学、光学、催化、艺术品保护和其他领域。尽管 AFM-IR 和 TERS 是独立发展的，最初针对不同的应用，但在过去 5 年中，快速的创新已经推动了这些在原理上互补的技术的性能远远超出了最初的预期，从而为它们的融合开辟了新的机会。因此，将突出显示细微的差异和互补性以及新兴的趋势和机会。
