Department of Psychiatry, Hospital Universitario Infanta Leonor, Gran Vía del Este 80, 28030, Madrid, Spain.
Department of Psychiatry and Psychology, Medical School, Complutense University, Av. Séneca, 2, 28040, Madrid, Spain.
Eat Weight Disord. 2021 Apr;26(3):847-857. doi: 10.1007/s40519-020-00922-7. Epub 2020 May 18.
There is a significant relationship between childhood trauma and the development of an eating disorder in adolescence or adulthood, possibly influenced by circulating levels of inflammatory parameters. The main objective is to identify and describe a subgroup of patients with eating disorders and a history of trauma in childhood or adolescence with differential clinical features.
An observational study on a sample of 55 patients who met the diagnostic criteria for any DSM-5 eating disorder was carried out. Inflammatory parameters in white blood cells were examined. Patients underwent different assessments, including clinical and personality scales.
Patients with a history of trauma had higher scores in the delirious and narcissistic items of the Millon Clinical Multiaxial Inventory (MCMI-II) (p < 0.05) and a higher score in the paranoid item of the SCID-5 Personality Disorders Version (SCID-5-PD) (p < 0.05). Patients with distinguishing personality features were grouped according to the Childhood Trauma Questionnaire sexual subscale. Tumor necrosis alpha (TNF-α) showed a significant association with childhood trauma history.
There is a profile of patients with eating disorders who have increased activity in the inflammatory pathways that, if identified precociously, can benefit from specifically aimed interventions.
Level V, observational study.
儿童期创伤与青少年或成年期饮食失调的发展之间存在显著关系，炎症参数的循环水平可能对此有影响。主要目的是确定和描述一组具有饮食失调和儿童期或青春期创伤史的患者，这些患者具有不同的临床特征。
对符合任何 DSM-5 饮食失调诊断标准的 55 例患者样本进行了观察性研究。检测了白细胞中的炎症参数。患者接受了不同的评估，包括临床和人格量表。
有创伤史的患者在 Millon 临床多轴量表（MCMI-II）的谵妄和自恋项目（p<0.05）和 SCID-5 人格障碍版本（SCID-5-PD）的偏执项目（p<0.05）中得分较高。根据儿童期创伤问卷的性分量表，具有区别人格特征的患者被分为不同的组。肿瘤坏死因子-α（TNF-α）与儿童期创伤史显著相关。
存在具有饮食失调的患者特征，这些患者的炎症途径活性增加，如果及早发现，他们可以受益于有针对性的干预措施。
V 级，观察性研究。
