Charité University of Medicine, Charitéplatz 1, 10117 Berlin, Germany.
Department of Orthopedic Surgery, Spine Surgery, Hadassah Medical Center, Kiryat Hadassah, P.O. Box 12000, 91120 Jerusalem, Israel.
Int J Endocrinol. 2015;2015:628740. doi: 10.1155/2015/628740. Epub 2015 Feb 24.
Malnutrition and starvation's possible adverse impacts on bone health and bone quality first came into the spotlight after the horrors of the Holocaust and the ghettos of World War II. Famine and food restrictions led to a mean caloric intake of 200-800 calories a day in the ghettos and concentration camps, resulting in catabolysis and starvation of the inhabitants and prisoners. Severely increased risks of fracture, poor bone mineral density, and decreased cortical strength were noted in several case series and descriptive reports addressing the medical issues of these individuals. A severe effect of severely diminished food intake and frequently concomitant calcium- and Vitamin D deficiencies was subsequently proven in both animal models and the most common cause of starvation in developed countries is anorexia nervosa. This review attempts to summarize the literature available on the impact of the metabolic response to Starvation on overall bone health and bone quality.
营养不良和饥饿对骨骼健康和骨质量的潜在不良影响，首先在大屠杀和二战犹太人区的恐怖之后引起了人们的关注。饥荒和食物限制导致犹太人区和集中营的居民和囚犯的日均热量摄入仅为 200-800 卡路里，导致分解代谢和饥饿。几项涉及这些个体医疗问题的病例系列和描述性报告指出，骨折风险显著增加、骨矿物质密度差和皮质骨强度降低。在动物模型和发达国家中最常见的饥饿原因——神经性厌食症中，都证明了严重的食物摄入减少和经常伴随的钙和维生素 D 缺乏的严重影响。本综述试图总结有关代谢对饥饿的反应对整体骨骼健康和骨质量的影响的现有文献。
