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Could the Inhibition of Endo-Lysosomal Two-Pore Channels (TPCs) by the Natural Flavonoid Naringenin Represent an Option to Fight SARS-CoV-2 Infection?

作者信息

Filippini Antonio, D'Amore Antonella, Palombi Fioretta, Carpaneto Armando

机构信息

Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, SAPIENZA University of Rome, Rome, Italy.

Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa, Genoa, Italy.

出版信息

Front Microbiol. 2020 Apr 30;11:970. doi: 10.3389/fmicb.2020.00970. eCollection 2020.

DOI:10.3389/fmicb.2020.00970
PMID:32425923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7204543/
Abstract
摘要

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Could the Inhibition of Endo-Lysosomal Two-Pore Channels (TPCs) by the Natural Flavonoid Naringenin Represent an Option to Fight SARS-CoV-2 Infection?天然黄酮类化合物柚皮苷对内膜溶酶体双孔通道（TPCs）的抑制作用能否成为对抗新型冠状病毒肺炎（SARS-CoV-2）感染的一种选择？
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本文引用的文献

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Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species.柚皮苷及其活性代谢产物柚皮素在大鼠、犬、人类体内的药代动力学与代谢以及种属差异
Front Pharmacol. 2020 Mar 27;11:364. doi: 10.3389/fphar.2020.00364. eCollection 2020.
2
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.SARS-CoV-2 刺突糖蛋白的特征及其对病毒进入的影响，以及与 SARS-CoV 的免疫交叉反应性。
Nat Commun. 2020 Mar 27;11(1):1620. doi: 10.1038/s41467-020-15562-9.
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Membrane binding proteins of coronaviruses.冠状病毒的膜结合蛋白
Future Virol. 2019 Apr;14(4):275-286. doi: 10.2217/fvl-2018-0144. Epub 2019 Apr 29.
4
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.激动剂介导的 TPC2 离子选择性转换差异促进溶酶体功能。
Elife. 2020 Mar 16;9:e54712. doi: 10.7554/eLife.54712.
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Of chloroquine and COVID-19.关于氯喹和 COVID-19。
Antiviral Res. 2020 May;177:104762. doi: 10.1016/j.antiviral.2020.104762. Epub 2020 Mar 5.
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges.严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）和 2019 年冠状病毒病（COVID-19）：疫情和挑战。
Int J Antimicrob Agents. 2020 Mar;55(3):105924. doi: 10.1016/j.ijantimicag.2020.105924. Epub 2020 Feb 17.
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Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance.脂门控单价离子流调节内吞运输并支持免疫监视。
Science. 2020 Jan 17;367(6475):301-305. doi: 10.1126/science.aaw9544. Epub 2019 Dec 5.
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Inhibition of SARS-CoV 3CL protease by flavonoids.黄酮类化合物对 SARS-CoV 3CL 蛋白酶的抑制作用。
J Enzyme Inhib Med Chem. 2020 Dec;35(1):145-151. doi: 10.1080/14756366.2019.1690480.
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Sci Rep. 2019 Nov 8;9(1):16348. doi: 10.1038/s41598-019-52626-3.