关于氯喹和 COVID-19。
Of chloroquine and COVID-19.
机构信息
Unité des Virus Emergents, UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection, 13005, Marseille, France.
出版信息
Antiviral Res. 2020 May;177:104762. doi: 10.1016/j.antiviral.2020.104762. Epub 2020 Mar 5.
Abstract
Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this information in light of previous experiments with chloroquine in the field of antiviral research.
摘要
最近的出版物引起了人们对氯喹（一种广泛使用的抗疟药物）在治疗新型出现的冠状病毒（SARS-CoV-2）感染患者方面可能有益的关注。科学界应该根据之前在抗病毒研究领域用氯喹进行的实验来考虑这一信息。
相似文献
1
Of chloroquine and COVID-19.关于氯喹和 COVID-19。
Antiviral Res. 2020 May;177:104762. doi: 10.1016/j.antiviral.2020.104762. Epub 2020 Mar 5.
2
Chloroquine and hydroxychloroquine in covid-19.氯喹和羟氯喹在2019冠状病毒病中的应用
BMJ. 2020 Apr 8;369:m1432. doi: 10.1136/bmj.m1432.
3
Chloroquine and its derivatives in the management of COVID-19: A scoping review.氯喹及其衍生物在COVID-19治疗中的应用：一项范围综述。
Biomedica. 2020 Oct 30;40(Supl. 2):80-95. doi: 10.7705/biomedica.5478.
4
Safety considerations for chloroquine and hydroxychloroquine in the treatment of COVID-19.氯喹和羟氯喹用于治疗新型冠状病毒肺炎的安全性考量
Clin Microbiol Infect. 2020 Sep;26(9):1276-1277. doi: 10.1016/j.cmi.2020.05.006. Epub 2020 May 16.
5
COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help.COVID-19、氯喹再利用和心脏安全问题：手性或许有帮助。
Molecules. 2020 Apr 16;25(8):1834. doi: 10.3390/molecules25081834.
6
COVID-19 and Antimalarial Drugs: Harms Outweigh Benefits.新型冠状病毒肺炎与抗疟药物：弊大于利
Am J Crit Care. 2020 Nov 1;29(6):489-492. doi: 10.4037/ajcc2020694.
7
Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection.氯喹、羟氯喹和阿奇霉素用于治疗新型冠状病毒肺炎（SARS-CoV-2感染）时的安全性考量
CMAJ. 2020 Apr 27;192(17):E450-E453. doi: 10.1503/cmaj.200528. Epub 2020 Apr 8.
8
Is Coronavirus Disease 2019 (COVID-19) seen less in countries more exposed to Malaria?在疟疾感染率较高的国家，2019冠状病毒病（COVID-19）的发病率是否较低？
Med Hypotheses. 2020 Jul;140:109756. doi: 10.1016/j.mehy.2020.109756. Epub 2020 Apr 22.
9
Ventricular arrhythmia risk due to chloroquine / hydroxychloroquine treatment for COVID-19: Should it be given.用于治疗新冠肺炎的氯喹/羟氯喹引发室性心律失常的风险：是否应该使用该药？
Indian Heart J. 2020 Mar-Apr;72(2):131-132. doi: 10.1016/j.ihj.2020.04.006. Epub 2020 Apr 27.
10
[Pharmacological characteristics of chloroquine and suggestions for its use in treatment of coronavirus disease 2019 (COVID-19)].氯喹的药理学特性及其用于治疗2019冠状病毒病（COVID-19）的建议
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2020 Apr 22;32(2):119-122. doi: 10.16250/j.32.1374.2020092.
引用本文的文献
1
Drug repositioning as a promising approach for the eradication of emerging and re-emerging viral agents.药物重新定位作为一种有前景的方法，用于根除新出现和再次出现的病毒病原体。
Mol Divers. 2025 Mar 18. doi: 10.1007/s11030-025-11131-8.
2
Autoimmune hepatitis under the COVID-19 veil: an analysis of the nature of potential associations.新冠疫情掩盖下的自身免疫性肝炎：潜在关联性质分析
Front Immunol. 2025 Jan 31;16:1510770. doi: 10.3389/fimmu.2025.1510770. eCollection 2025.
3
Advancements in the development of antivirals against SARS-Coronavirus.抗SARS冠状病毒抗病毒药物的研发进展。
Front Cell Infect Microbiol. 2025 Jan 23;15:1520811. doi: 10.3389/fcimb.2025.1520811. eCollection 2025.
4
study MM/GBSA binding free energy and molecular dynamics simulation of some designed remdesivir derivatives as the inhibitory potential of SARS-CoV-2 main protease.研究一些设计的瑞德西韦衍生物作为SARS-CoV-2主要蛋白酶抑制潜力的MM/GBSA结合自由能和分子动力学模拟。
Res Pharm Sci. 2024 Feb 6;19(1):29-41. doi: 10.4103/1735-5362.394818. eCollection 2024 Feb.
5
A Narrative Overview of Coronavirus Infection: Clinical Signs and Symptoms, Viral Entry and Replication, Treatment Modalities, and Management.冠状病毒感染的叙述性概述：临床体征和症状、病毒进入和复制、治疗方式和管理。
Curr Top Med Chem. 2024;24(21):1883-1916. doi: 10.2174/0115680266296095240529114058.
6
[Pharmacological treatment of COVID-19: Narrative review of the Working Group in Infectious Diseases and Sepsis (GTEIS) and the Working Groups in Transfusions and Blood Products (GTTH)].[新型冠状病毒肺炎的药物治疗：传染病与脓毒症工作组（GTEIS）及输血与血液制品工作组（GTTH）的叙述性综述]
Med Intensiva. 2021 Mar;45(2):104-121. doi: 10.1016/j.medin.2020.06.017. Epub 2020 Jul 11.
7
A comprehensive review on pharmacologic agents, immunotherapies and supportive therapeutics for COVID-19.关于COVID-19的药物制剂、免疫疗法和支持性疗法的全面综述。
Narra J. 2022 Dec;2(3):e92. doi: 10.52225/narra.v2i3.92. Epub 2022 Dec 8.
8
Identification of Novel Non-Nucleoside Inhibitors of Zika Virus NS5 Protein Targeting MTase Activity.鉴定靶向 Zika 病毒 NS5 蛋白甲基转移酶活性的新型非核苷抑制剂。
Int J Mol Sci. 2024 Feb 19;25(4):2437. doi: 10.3390/ijms25042437.
9
Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells.羟氯喹在人TK6细胞中的弱遗传毒性评估。
Toxicol Lett. 2024 Mar;393:84-95. doi: 10.1016/j.toxlet.2024.01.012. Epub 2024 Feb 2.
10
An Update on SARS-CoV-2 Clinical Trial Results-What We Can Learn for the Next Pandemic.关于 SARS-CoV-2 临床试验结果的最新信息——我们可以从中学到什么以应对下一次大流行。
Int J Mol Sci. 2023 Dec 26;25(1):354. doi: 10.3390/ijms25010354.
本文引用的文献
1
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.突破：磷酸氯喹在临床研究中显示出对 COVID-19 相关肺炎的明显疗效。
Biosci Trends. 2020 Mar 16;14(1):72-73. doi: 10.5582/bst.2020.01047. Epub 2020 Feb 19.
2
Chloroquine for the 2019 novel coronavirus SARS-CoV-2.氯喹用于2019新型冠状病毒SARS-CoV-2。
Int J Antimicrob Agents. 2020 Mar;55(3):105923. doi: 10.1016/j.ijantimicag.2020.105923. Epub 2020 Feb 15.
3
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.瑞德西韦和氯喹在体外能有效抑制新出现的新型冠状病毒（2019 - 新冠病毒）。
Cell Res. 2020 Mar;30(3):269-271. doi: 10.1038/s41422-020-0282-0. Epub 2020 Feb 4.
4
Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection.氯喹治疗增强基孔肯雅热病毒感染的矛盾效应。
Viruses. 2018 May 17;10(5):268. doi: 10.3390/v10050268.
5
An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease.评估氯喹对手足口病的广谱抗病毒作用。
Antiviral Res. 2018 Jan;149:143-149. doi: 10.1016/j.antiviral.2017.11.017. Epub 2017 Nov 22.
6
Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice.氯喹，一种美国食品药品监督管理局批准的药物，可预防寨卡病毒感染及其引起的小鼠先天性小头畸形。
EBioMedicine. 2017 Oct;24:189-194. doi: 10.1016/j.ebiom.2017.09.034. Epub 2017 Sep 28.
7
Hydroxychloroquine augments early virological response to pegylated interferon plus ribavirin in genotype-4 chronic hepatitis C patients.羟氯喹增强4型慢性丙型肝炎患者对聚乙二醇化干扰素加利巴韦林的早期病毒学应答。
J Med Virol. 2016 Dec;88(12):2170-2178. doi: 10.1002/jmv.24575. Epub 2016 May 25.
8
New use of an old drug: chloroquine reduces viral and ALT levels in HCV non-responders (a randomized, triple-blind, placebo-controlled pilot trial).一种老药的新用途：氯喹降低丙型肝炎病毒无反应者的病毒水平和谷丙转氨酶水平（一项随机、三盲、安慰剂对照的试点试验）
Can J Physiol Pharmacol. 2016 Jun;94(6):613-9. doi: 10.1139/cjpp-2015-0507. Epub 2016 Jan 15.
9
Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and disease in the in vivo guinea pig model.氯喹在体外可抑制埃博拉病毒复制，但在体内豚鼠模型中未能预防感染和疾病。
J Gen Virol. 2015 Dec;96(12):3484-3492. doi: 10.1099/jgv.0.000309.
10
The enigma of the clandestine association between chloroquine and HIV-1 infection.氯喹与HIV-1感染之间秘密关联的谜团。
HIV Med. 2015 Nov;16(10):585-90. doi: 10.1111/hiv.12295. Epub 2015 Aug 4.
Zotero 插件