Laboratory of Clinical Immunology and Department of Clinical Hematology, Sofiamed University Hospital, Sofia, Bulgaria.
Faculty of Biology, Sofia University, Sofia, Bulgaria.
Front Immunol. 2020 Apr 30;11:932. doi: 10.3389/fimmu.2020.00932. eCollection 2020.
While studying the human public IgM igome as represented by a library of 224,087 linear mimotopes, three exact matches to peptides in the proteins of SARS-CoV-2 were found: two in the open reading frame 1ab and one in the spike protein. Joining the efforts to fast track SARS-CoV-2 vaccine development, here we describe briefly these potential epitopes in comparison to mimotopes representing peptides of SARS-CoV, HCoV 229E and OC43.
在研究由 224087 个线性模拟表位组成的人类公共 IgM Igome 时，发现了三个与 SARS-CoV-2 蛋白中的肽完全匹配的模拟表位：两个在开放阅读框 1ab 中，一个在刺突蛋白中。为了加快 SARS-CoV-2 疫苗的开发，我们在这里简要描述了这些潜在的表位，与代表 SARS-CoV、HCoV 229E 和 OC43 肽的模拟表位进行了比较。
