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发热揭示小儿患者的 Brugada 综合征:一例报告

Fever Unmasked Brugada Syndrome in Pediatric Patient: A Case Report.

作者信息

Mirzapolos Orhay, Marshall Perry, Brill April

机构信息

Midwestern University, Department of Emergency Medicine, Downers Grove, Illinois.

出版信息

Clin Pract Cases Emerg Med. 2020 Apr 23;4(2):244-246. doi: 10.5811/cpcem.2020.2.44418. eCollection 2020 May.

DOI:10.5811/cpcem.2020.2.44418
PMID:32426684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7220012/
Abstract

INTRODUCTION

Brugada syndrome is an arrhythmogenic disorder that is a known cause of sudden cardiac death. It is characterized by a pattern of ST segment elevation in the precordial leads on an electrocardiogram (EKG) due to a sodium channelopathy.

CASE REPORT

This case report highlights the case of a five-year-old female who presented to the emergency department with a febrile viral illness and had an EKG consistent with Brugada syndrome.

DISCUSSION

Fever is known to accentuate or unmask EKG changes associated with Brugada due to temperature sensitivity of the sodium channels.

CONCLUSION

Febrile patients with Brugada are at particular risk for fatal ventricular arrhythmias and fevers should be treated aggressively by the emergency medicine provider. Emergency medicine providers should also consider admitting febrile patients with Brugada syndrome who do not have an automatic implantable cardioverter-defibrillator for cardiac monitoring.

摘要

引言

Brugada综合征是一种致心律失常性疾病,是心脏性猝死的已知原因。其特征是由于钠通道病导致心电图(EKG)胸前导联ST段抬高。

病例报告

本病例报告重点介绍了一名五岁女性,她因发热性病毒感染就诊于急诊科,其心电图与Brugada综合征相符。

讨论

由于钠通道的温度敏感性,已知发热会加重或掩盖与Brugada相关的心电图变化。

结论

患有Brugada综合征的发热患者尤其有发生致命性室性心律失常的风险,急诊医学医生应积极治疗发热。急诊医学医生还应考虑收治没有自动植入式心律转复除颤器的Brugada综合征发热患者进行心脏监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24e/7220012/a5981ebcfc0e/cpcem-04-244-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24e/7220012/a5981ebcfc0e/cpcem-04-244-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24e/7220012/a5981ebcfc0e/cpcem-04-244-g001.jpg

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本文引用的文献

1
A pediatric case of Brugada syndrome diagnosed by fever-provoked ventricular tachycardia.一例通过发热诱发室性心动过速诊断的小儿Brugada综合征病例。
Korean J Pediatr. 2014 Aug;57(8):374-8. doi: 10.3345/kjp.2014.57.8.374. Epub 2014 Aug 25.
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Diagnosis and management of Brugada Syndrome. Brugada 综合征的诊断与治疗。
Heart Lung Circ. 2011 Dec;20(12):751-6. doi: 10.1016/j.hlc.2011.07.014. Epub 2011 Sep 22.
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Brugada syndrome unmasked by fever.发热诱发的 Brugada 综合征
Mil Med. 2011 Aug;176(8):946-9. doi: 10.7205/milmed-d-10-00458.
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An unusual case of Brugada syndrome in a 10-year-old child with fevers.一名10岁发热儿童的罕见布加综合征病例。
Congenit Heart Dis. 2010 Nov-Dec;5(6):594-8. doi: 10.1111/j.1747-0803.2010.00382.x.
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Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome.发热诱发 Brugada 综合征和 2 型长 QT 综合征的室性心律失常。
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A newly characterized SCN5A mutation underlying Brugada syndrome unmasked by hyperthermia.一种新发现的与Brugada综合征相关的SCN5A突变,在高温下被揭示出来。
J Cardiovasc Electrophysiol. 2003 Apr;14(4):407-11. doi: 10.1046/j.1540-8167.2003.02379.x.