Department of Surgery, Vanderbilt University Medical Center , Nashville, Tennessee, USA.
Department of Orthopedics, Emory School of Medicine, Atlanta, Georgia, USA.
J Clin Invest. 2020 Aug 3;130(8):4396-4410. doi: 10.1172/JCI123597.
Esophageal atresia (EA/TEF) is a common congenital abnormality present in 1 of 4000 births. Here we show that atretic esophagi lack Noggin (NOG) expression, resulting in immature esophagus that contains respiratory glands. Moreover, when using mouse esophageal organoid units (EOUs) or tracheal organoid units (TOUs) as a model of foregut development and differentiation in vitro, NOG determines whether foregut progenitors differentiate toward esophageal or tracheal epithelium. These results indicate that NOG is a critical regulator of cell fate decisions between esophageal and pulmonary morphogenesis, and its lack of expression results in EA/TEF.
食管闭锁（EA/TEF）是一种常见的先天性异常，每 4000 例出生中就有 1 例。在这里，我们表明闭锁的食管缺乏 Noggin（NOG）表达，导致不成熟的食管含有呼吸腺。此外，当使用小鼠食管类器官单位（EOUs）或气管类器官单位（TOUs）作为体外前肠发育和分化的模型时，NOG 决定前肠祖细胞是分化为食管还是气管上皮。这些结果表明，NOG 是食管和肺形态发生之间细胞命运决定的关键调节剂，其表达缺失导致 EA/TEF。
