假二元磷脂体系的相图。I. 链长差异对脑磷脂/脑磷脂/水体系混溶性的影响。

Phase diagrams of pseudo-binary phospholipid systems. I. Influence of the chain length differences on the miscibility properties of cephaline/cephaline/water systems.

作者信息

Dörfler H D, Brezesinski G, Miethe P

机构信息

Sektion Chemie der Technischen Universität Dresden, G.D.R.

出版信息

Chem Phys Lipids. 1988 Oct;48(3-4):245-54. doi: 10.1016/0009-3084(88)90094-1.

DOI:10.1016/0009-3084(88)90094-1

PMID:3242952

Abstract

The miscibility properties of homologous cephalines (PEs) were studied by means of differential scanning calorimetry (DSC). The phase diagrams of 5 pseudo-binary cephaline/cephaline/water systems (50% water) are discussed. In the high temperature L alpha-phase, all the homologous cephalines of fatty acid chain length from C = 12 to C = 18 were completely miscible. On the other hand in the low temperature L beta-phase, a miscibility gap occurred in dependence on the differences of the acyl chain lengths. Further, a distinct succession of the phase diagram types was observed according to increasing chain length differences of the PEs: complete miscibility (systems di-(C12:O)-PE/di-(C14:O)-PE/H2O; di-(C14:O)-PE/di-C(16:O)-PE/H2O)----peritectic mixing behaviour (systems di-(C12:O)-PE/di-(C16:O)-PE/H2O; di-(C14:O)-PE/di-(C18:O)-PE/H2O)----eutectic mixing behaviour (system di-(C12:O)-PE/di-(C18:O)-PE/H2O). The change in the type of phase diagram from azeotropic to semi-azeotropic and from semi-azeotropic to eutectic is interpreted by means of the Landau theory.

摘要

通过差示扫描量热法（DSC）研究了同源脑磷脂（PEs）的混溶性。讨论了5个伪二元脑磷脂/脑磷脂/水体系（50%水）的相图。在高温Lα相中，脂肪酸链长度从C = 12到C = 18的所有同源脑磷脂完全互溶。另一方面，在低温Lβ相中，根据酰基链长度的差异出现了混溶间隙。此外，根据PEs链长差异的增加，观察到相图类型有明显的连续变化：完全互溶（体系二（C12:O）-PE/二（C14:O）-PE/H2O；二（C14:O）-PE/二-C（16:O）-PE/H2O）----包晶混合行为（体系二（C12:O）-PE/二（C16:O）-PE/H2O；二（C14:O）-PE/二（C18:O）-PE/H2O）----共晶混合行为（体系二（C12:O）-PE/二（C18:O）-PE/H2O）。利用朗道理论解释了相图类型从共沸到半共沸以及从半共沸到共晶的变化。