Sugár I P, Monticelli G
Biophys J. 1985 Aug;48(2):283-8. doi: 10.1016/S0006-3495(85)83781-4.
Basic relationships between the phase diagrams, previously considered independent of each other, are described. Phase diagrams of two-component phosphatidylcholine/phosphatidylcholine (PC/PC), phosphatidylethanolamine/phosphatidylethanolamine (PE/PE), and PC/PE lipid membranes are systematically investigated by means of the Landau theory. While gradually changing the chain length of one of the components, a characteristic peritectic-miscible-azeotropic-semiazeotropic-eutectic (P-M-A-S-E) series of the phase diagram was found in the PC/PE system and a peritectic-miscible-one-component-miscible-peritectic (P-M-O-M-P) series was found in the PC/PC and PE/PE systems. These serial catastrophic changes in the phase diagrams could be explained by the fusion and birth of the mixed phase regions in the phase diagram. Finally when we constructed the superdiagrams, we obtained all of the possible series of the phase diagrams in a wide class of the two-component mixtures. Moreover, one can predict the type of the phase diagram when the components r and p contain equal-length saturated hydrocarbon chains. Depending on the relationships between the chain lengths (L, Lp) and that on the phase transition temperatures of the pure components (Tr, Tp), the system is: miscible (M), if 0 < Tr(L) - Tp(L) < 5 degrees C and L -Lp > 0, azeotropic (A), if 0 < T,(L) - Tp(L) < 5 degrees C and L -Lp < 0, peritectic (P), if T,(L) - Tp(L) > 40 degrees C and L -Lp - 0, eutectic (E), if Tr(L) - Tp(L) >40 degrees C and L - Lp <0,while it is M or P if 5 degrees C< Tr(L) - Tp(L) <40 degrees C and L - Lp>-0,and E,S,or Aif 5 degrees C < Tr(L) - Tp(L) < 40 degrees C and L,-Lp < 0.
本文描述了之前认为相互独立的相图之间的基本关系。通过朗道理论系统地研究了双组分磷脂酰胆碱/磷脂酰胆碱（PC/PC）、磷脂酰乙醇胺/磷脂酰乙醇胺（PE/PE）以及PC/PE脂质膜的相图。在逐渐改变其中一种组分的链长时，在PC/PE体系中发现了具有特征性的包晶 - 互溶 - 共沸 - 半共沸 - 低共熔（P - M - A - S - E）系列相图，在PC/PC和PE/PE体系中发现了包晶 - 互溶 - 单组分互溶 - 包晶（P - M - O - M - P）系列相图。相图中的这些系列突变变化可以通过相图中混合相区域的融合和产生来解释。最后，当构建超相图时，我们得到了一大类双组分混合物中所有可能的相图系列。此外，当组分r和p包含等长饱和烃链时，可以预测相图的类型。根据链长（L，Lp）之间的关系以及纯组分的相变温度（Tr，Tp）之间的关系，该体系为：若0 < Tr(L) - Tp(L) < 5℃且L - Lp > 0，则为互溶（M）；若0 < T,(L) - Tp(L) < 5℃且L - Lp < 0，则为共沸（A）；若T,(L) - Tp(L) > 40℃且L - Lp - 0，则为包晶（P）；若Tr(L) - Tp(L) >40℃且L - Lp <0，则为低共熔（E）；而当5℃< Tr(L) - Tp(L) <40℃且L - Lp>-0时，为M或P；当5℃ < Tr(L) - Tp(L) < 40℃且L,-Lp < 0时，为E、S或A。
