Nutrition and Clinical Trials Unit, GENYAL Platform IMDEA-Food Institute, CEI UAM + CSIC, 28049 Madrid, Spain.
Biostatistics and Bioinformatics Unit, IMDEA Food Institute, CEI UAM+CSIC, Ctra. De Canto Blanco 8, 28049 Madrid, Spain.
Genes (Basel). 2020 May 17;11(5):560. doi: 10.3390/genes11050560.
(1) Background: Childhood rapid weight gain during development has been postulated as a predictor of obesity. The objective of this study was to investigate the effect of single nucleotide polymorphisms (SNPs) on the annual weight gain and height growth, as well as identifying possible lifestyle factors involved. (2) Methods: As part of the GENYAL study, 221 children (6-8 years old) of Madrid (Spain) were enrolled. A total of 11 SNPs associated with high childhood body mass indexes (BMIs) were assessed. Anthropometric measurements, dietary and physical activity data, were collected in 2017 and 2018. Bonferroni-corrected linear models were used to fit the data. (3) Results: A significant association between the Q223R and the weight growth was found, showing a different behavior between GA and GG genotypes ( = 0.001). Regarding lifestyle factors, an interaction between Q223R genotypes and total active weekly hours/week to predict the weight growth (kg/year) was observed ( = 0.023). In all the genotypes, a beneficial effect against rapid weight growth was observed, but the effect size of the interaction was much more significant in homozygous (GG) minor homozygous (β = -0.61 (-0.95, -0.26) versus heterozygous (AG) and wild-type homozygous (AA) genotypes (β = -0.07 (-0.24, 0.09) and β = -0.12 (-0.32, 0.08), respectively). (4) Conclusions: These results may contribute to more personalized recommendations to prevent childhood obesity.
(1) 背景：儿童发育过程中的快速体重增长被认为是肥胖的预测指标。本研究旨在探讨单核苷酸多态性（SNPs）对年体重增长和身高增长的影响，并确定可能涉及的生活方式因素。(2) 方法：作为 GENYAL 研究的一部分，共纳入了 221 名马德里（西班牙）的 6-8 岁儿童。评估了与儿童高体质量指数（BMI）相关的 11 个 SNPs。2017 年和 2018 年收集了体格测量、饮食和体力活动数据。使用 Bonferroni 校正的线性模型拟合数据。(3) 结果：发现 Q223R 与体重增长之间存在显著关联，GA 和 GG 基因型之间的行为表现不同（ = 0.001）。关于生活方式因素，观察到 Q223R 基因型与每周总活跃小时数/周之间存在交互作用，可预测体重增长（kg/年）（ = 0.023）。在所有基因型中，均观察到对快速体重增长的有益作用，但杂合子（AG）和野生型纯合子（AA）基因型中交互作用的效应大小更为显著（β=-0.61（-0.95，-0.26），而纯合子（GG）基因型为β=-0.07（-0.24，0.09）和β=-0.12（-0.32，0.08））。(4) 结论：这些结果可能有助于制定更个性化的预防儿童肥胖症的建议。
