Holgate S T, Jackson L, Watson H K, Ganderton M A
Faculty of Medicine, University of Southampton, U.K.
Clin Allergy. 1988 Nov;18(6):549-56. doi: 10.1111/j.1365-2222.1988.tb02906.x.
The pollen of Parietaria species is a well-recognized and important inhalant allergen in the Mediterranean area. Parietaria judaica (Pellitory-of-the-Wall) is native to the U.K., flowering from June to September, but is not usually considered to be of any clinical importance by U.K. allergists. We skin tested 62 patients with a clinical history of summer seasonal respiratory symptoms and a control group of 11 patients with perennial respiratory symptoms only. Each was skin tested in duplicate with extracts of grass pollen, birch pollen, Parietaria pollen, Dermatophagoides pteronyssinus, Cladosporium, Alternaria, nettle pollen and negative and positive controls, and serum samples were collected for RAST assays for Parietaria and nettle. Eight of the 62 patients in the main group showed skin reactivity to Parietaria. Five of these eight had never visited the Mediterranean area and therefore it is possible that sensitization occurred in the U.K. Thirteen of the 62 patients were skin reactive to nettle but there was no correlation between skin reactivity to Parietaria and nettle. This supports a recent report that, despite their close botanical relationship, no antigenic cross-reactivity exists between the two species. No correlation was seen between skin reactivity and serum RAST activity to Parietaria or nettle. It is not known whether exposure to Parietaria pollen contributes to the seasonal symptoms of the patients found to be skin reactive. None of the 11 patients in the control group was skin reactive to Parietaria.
墙草属植物的花粉是地中海地区一种广为人知且重要的吸入性变应原。墙草原产于英国，6月至9月开花，但英国过敏症专科医生通常认为其不具有任何临床重要性。我们对62例有夏季季节性呼吸道症状临床病史的患者以及11例仅有常年性呼吸道症状的对照组患者进行了皮肤试验。每组患者均用草花粉、桦树花粉、墙草花粉、屋尘螨、枝孢属、链格孢属、荨麻花粉提取物以及阴性和阳性对照进行了重复皮肤试验，并采集血清样本进行墙草和荨麻的放射变应原吸附试验（RAST）。主要组的62例患者中有8例对墙草表现出皮肤反应性。这8例中的5例从未去过地中海地区，因此有可能是在英国发生了致敏。62例患者中有13例对荨麻有皮肤反应，但对墙草和荨麻的皮肤反应性之间没有相关性。这支持了最近的一份报告，即尽管这两个物种在植物学上关系密切，但它们之间不存在抗原交叉反应性。对墙草或荨麻的皮肤反应性与血清RAST活性之间未发现相关性。尚不清楚接触墙草花粉是否会导致被发现有皮肤反应性的患者出现季节性症状。对照组的11例患者中没有一例对墙草有皮肤反应。
