Chao Fan, Wang Shiyu, Zhang Cong, Han Dunsheng, Xu Guoxiong, Chen Gang
Department of Urology, Jinshan Hospital, Fudan University, Shanghai, China.
Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, China.
Front Cell Dev Biol. 2021 Jul 27;9:681163. doi: 10.3389/fcell.2021.681163. eCollection 2021.
Prostate cancer is one of the most common malignant tumors that threaten the health of men. It is urgent to explore new molecular targets and develop new drugs for the treatment of prostate cancer. Circular RNAs (circRNAs) are aberrantly expressed in various malignant tumors. The dysregulated circRNAs are involved in the metastasis, tumor growth, drug resistance, and immunosuppression of malignant tumors. The present review systematically summarized publications concerning the biological implications of circRNAs in prostate cancer. The PubMed and Web of Science databases were used to retrieve publications concerning circRNAs and prostate cancer until June 16, 2021. The following keywords were used in the literature search: (circRNA OR circular RNA) AND prostate cancer. 73 publications were enrolled in the present systematic review to summarize the role of circRNAs in prostate cancer. The dysregulated and functional circRNAs were involved in the cell cycle, proliferation, migration, invasion, metastasis, drug resistance and radiosensitivity of prostate cancer. In addition, circRNAs could function through EVs and serve as prognostic and diagnostic biomarkers. Certain circRNAs were correlated with clinicopathological features of prostate cancer. A comprehensive review of the molecular mechanism of the tumorigenesis and progression of prostate cancer may contribute to the development of new therapies of prostate cancer in the future.
前列腺癌是威胁男性健康的最常见恶性肿瘤之一。探索新的分子靶点并开发治疗前列腺癌的新药迫在眉睫。环状RNA（circRNA）在各种恶性肿瘤中异常表达。失调的circRNA参与恶性肿瘤的转移、肿瘤生长、耐药性和免疫抑制。本综述系统总结了关于circRNA在前列腺癌中的生物学意义的出版物。利用PubMed和Web of Science数据库检索截至2021年6月16日关于circRNA和前列腺癌的出版物。文献检索中使用了以下关键词：（circRNA或环状RNA）和前列腺癌。本系统综述纳入了73篇出版物，以总结circRNA在前列腺癌中的作用。失调的和具有功能的circRNA参与前列腺癌的细胞周期、增殖、迁移、侵袭、转移、耐药性和放射敏感性。此外，circRNA可通过细胞外囊泡发挥作用，并可作为预后和诊断生物标志物。某些circRNA与前列腺癌的临床病理特征相关。对前列腺癌发生和进展的分子机制进行全面综述可能有助于未来前列腺癌新疗法的开发。
