Li Lisha, Li Yanjing, Bai Yuxian
Department of Gastrointestinal Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, People's Republic of China.
Cancer Manag Res. 2020 Apr 30;12:3033-3043. doi: 10.2147/CMAR.S246948. eCollection 2020.
Gasdermin B (GSDMB) belongs to the gasdermin (GSDM) family which may adopt different mechanisms of intramolecular domain interactions to modulate their lipid-binding and pore-forming activities. The GSDM family has regulatory functions in cell proliferation and differentiation, especially in pyroptosis process. Pyroptosis is a pro-inflammatory form of regulated cell death and is designed to attract a nonspecific innate response to the site of infection. For cancer cells, the activation of pyroptosis may promote cell death and exert anticancer properties. Also, recent studies have observed the pyroptosis-like features in GSDMB and some researches have shown that GSDMB overexpression occurred in several kinds of cancers; these findings bring a contradiction with the participation of GSDMB in pyroptosis. Although people pay less attention to GSDMB, it still has some essential research value. It is a paradox that GSDMB might participate in programmed cell death, which might put forward a research direction of therapeutic targets for cancer. Here, we review the possible progress of how GSDMB participated in this inflammatory regulation mechanistically and the potential functions of GSDMB in cancer.
Gasdermin B（GSDMB）属于gasdermin（GSDM）家族，该家族可能采用不同的分子内结构域相互作用机制来调节其脂质结合和孔形成活性。GSDM家族在细胞增殖和分化中具有调节功能，尤其是在细胞焦亡过程中。细胞焦亡是一种促炎形式的程序性细胞死亡，旨在吸引对感染部位的非特异性先天反应。对于癌细胞而言，细胞焦亡的激活可能促进细胞死亡并发挥抗癌特性。此外，最近的研究观察到GSDMB具有类似细胞焦亡的特征，并且一些研究表明GSDMB在几种癌症中过表达；这些发现与GSDMB参与细胞焦亡相矛盾。尽管人们对GSDMB的关注较少，但它仍具有一些重要的研究价值。GSDMB可能参与程序性细胞死亡这一矛盾现象，可能为癌症治疗靶点提出一个研究方向。在此，我们综述了GSDMB如何机械地参与这种炎症调节的可能进展以及GSDMB在癌症中的潜在功能。
