Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Sapienza Università di Roma, Rome, Italy.
Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
Front Immunol. 2020 May 5;11:682. doi: 10.3389/fimmu.2020.00682. eCollection 2020.
"Location, location, and location": according to this mantra, the place where living beings settle has a key impact on the success of their activities; in turn, the living beings can, in many ways, modify their environment. This idea has now become more and more true for T cells. The ability of T cells to recirculate throughout blood or lymph, or to stably reside in certain tissues, turned out to determine immunity to pathogens, and tumors. If location matters also for human beings, the inspiring environment of Capri Island has contributed to the success of the EFIS-EJI Ruggero Ceppellini Advanced School of Immunology focused on "T cell memory," held in Anacapri from October 12, 2018 to October 15, 2018. In this minireview, we would like to highlight some novel concepts about T cell migration and residency and discuss their implications in relation to recent advances in the field, including the mechanisms regulating compartmentalization and cell cycle entry of T cells during activation, the role of mitochondrial metabolism in T cell movement, and the residency of regulatory T cells.
“位置、位置、还是位置”：根据这一准则，生物栖息的地点对其活动的成败有关键影响；反过来，生物在许多方面也可以改变其环境。这一理念如今对 T 细胞来说越来越正确。T 细胞在血液或淋巴中循环，或稳定地驻留在某些组织中的能力，决定了对病原体和肿瘤的免疫。如果位置对人类也很重要，那么卡普里岛鼓舞人心的环境促成了 2018 年 10 月 12 日至 15 日在阿纳卡普里举行的以“T 细胞记忆”为主题的 EFIS-EJI Ruggero Ceppellini 高级免疫学研讨会的成功。在这篇简评中，我们想强调一些关于 T 细胞迁移和驻留的新观点，并讨论它们与该领域的最新进展的关系，包括调节 T 细胞在激活过程中分区和进入细胞周期的机制、线粒体代谢在 T 细胞运动中的作用以及调节性 T 细胞的驻留。
