Wollein Waldetoft Kristofer, Råberg Lars, Lood Rolf
School of Biological Sciences Georgia Institute of Technology Atlanta GA USA.
Department of Biology Lund University Lund Sweden.
Evol Appl. 2020 Mar 31;13(5):879-888. doi: 10.1111/eva.12952. eCollection 2020 May.
Key topics in the study of host-microbe interactions-such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria-would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework for the integrated study of host-microbe interactions. This framework partitions the health effects of microbes and the effector molecules they produce into components with different evolutionary implications. It thereby facilitates the prediction of evolutionary responses to inhibition and exploitation of specific molecular mechanisms.
宿主-微生物相互作用研究中的关键主题，如耐药性的预防和细菌有益作用的利用，将受益于机械论和进化方法的协同努力。但由于学术传统的差异，一个领域获得的见解很少能惠及另一个领域。在此，我们开发了一个用于宿主-微生物相互作用综合研究的概念和分析框架。该框架将微生物及其产生的效应分子对健康的影响划分为具有不同进化意义的组成部分。从而有助于预测对特定分子机制的抑制和利用所产生的进化反应。
